General Information of Drug Transporter (DT)
DT ID	DTD0250 Transporter Info
Gene Name	SLC29A4
Protein Name	Equilibrative nucleoside transporter 4
Gene ID	222962
UniProt ID	Q7RTT9
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs3889348
Site of GPD	chr7:5298844 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>C / A>G
Minor Allele Frequency	A=0.2620/518 (Global)
Allele G	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Metformin	N.A.	Gastrointestinal Toxicity	Allele G is associated with increased severity of gastrointestinal toxicity when treated with metformin in people with Diabetes Mellitus, Type 2 as compared to allele A.		[ 1]
Genetic Polymorphism	rs10234709
Site of GPD	chr7:5335911 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>A / C>T
Minor Allele Frequency	C=0.6900/1365 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Metformin	N.A.	Gastrointestinal Toxicity	Allele A is associated with decreased response to metformin in people with Diabetes Mellitus, Type 2 as compared to allele C.		[ 2]
References
1	PMAT variant rs3889348 is associated with metformin-induced gastrointestinal among Chinese Type 2 diabetes patients. Pharmacogenomics. 2023 Jul;24(10):551-560.
2	Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics. Stud Health Technol Inform. 2015;210:914-8.

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