Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0171 Transporter Info | ||||
| Gene Name | SLC25A13 | ||||
| Protein Name | Calcium-binding mitochondrial carrier protein Aralar2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs768172 | ||||
| Site of GPD | chr7:96176391 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | A>G / A>T | ||||
| Minor Allele Frequency | A=0.4580/906 (Global) | ||||
| Allele A | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Irinotecan | N.A. | Diarrhea | Allele A is not associated with likelihood of Diarrhea when treated with irinotecan in people with Neoplasms as compared to allele T. | [ 1] | |
| References | |||||
| 1 | Application of a combination of a knowledge-based algorithm and 2-stage screening to hypothesis-free genomic data on irinotecan-treated patients for identification of a candidate single nucleotide polymorphism related to an adverse effect. PLoS One. 2014;9(8):e105160. | ||||
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