General Information of Drug Transporter (DT)
DT ID	DTD0130 Transporter Info
Gene Name	SLC1A2
Protein Name	Excitatory amino acid transporter 2
Gene ID	6506
UniProt ID	P43004
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs4354668
Site of GPD	chr11:35419429 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>G
Minor Allele Frequency	G=0.3980/1534 (Global)
Allele G	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Botulinum Toxin Type A	N.A.	Diarrhea	Allele G is not associated with response to botulinum toxin type a in women with Migraine NOS as compared to allele T.		[ 1]
N.A.	N.A.	Schizophrenia	Correlated with the risk of schizophrenia (compare with T)		[ 2]
Genetic Polymorphism	rs3794087
Site of GPD	chr11:35308068 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>T
Minor Allele Frequency	T=0.1597/800 (Global)
Allele G	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
N.A.	N.A.	Migraine	Irrelevant to the risk for migraine (compare with wide type)		[ 3]
References
1	CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA. J Headache Pain. 2019 Apr 23;20(1):39.
2	Common variants in SLC1A2 and schizophrenia: Association and cognitive function in patients with schizophrenia and healthy individuals. Schizophr Res. 2015 Dec;169(1-3):128-134.
3	SLC1A2 rs3794087 variant and risk for migraine. J Neurol Sci. 2014 Mar 15;338(1-2):92-5.

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