General Information of Drug Transporter (DT)
DT ID	DTD0116 Transporter Info
Gene Name	SLC17A3
Protein Name	Sodium-dependent phosphate transport protein 4
Gene ID	10786
UniProt ID	O00476
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs548987
Site of GPD	chr6:25869143 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>C
Minor Allele Frequency	C=0.0980/439 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antihypertensive Drug	N.A.	Small Vessel Disease Subtype of Ischemic Stroke	Correlated with the small vessel disease subtype of ischemic stroke in Chinese population (compare with allele G)		[ 1]
Genetic Polymorphism	rs34376145
Site of GPD	chr6:25850821 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>A / C>T
Minor Allele Frequency	C=0.9980/1975 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Bumetanide	N.A.	Juvenile Rheumatoid Arthritis	Allele A is associated with decreased transport of SLC17A3 when assayed with bumetanide in Xenopus oocytes as compared to allele C.		[ 2]
Genetic Polymorphism	rs34902660
Site of GPD	chr6:25850874 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>A
Minor Allele Frequency	C=0.9930/1965 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Bumetanide	N.A.	Juvenile Rheumatoid Arthritis	Allele A is associated with decreased transport of SLC17A3 when assayed with bumetanide in Xenopus oocytes as compared to allele C.		[ 2]
Genetic Polymorphism	rs11966370
Site of GPD	chr6:25849943 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Bumetanide	N.A.	Juvenile Rheumatoid Arthritis	Allele A is associated with decreased transport of SLC17A3 when assayed with bumetanide in Xenopus oocytes as compared to allele G.		[ 2]
Genetic Polymorphism	rs56027330
Site of GPD	chr6:25850617 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>T
Minor Allele Frequency	C=0.9310/1842 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Bumetanide	N.A.	Juvenile Rheumatoid Arthritis	Allele T is associated with decreased transport of SLC17A3 when assayed with bumetanide in Xenopus oocytes as compared to allele C.		[ 2]
References
1	The homocysteine associated variant rs548987 of SLC17A3 confers susceptibility to ischemic stroke in Chinese population. J Neurol Sci. 2016 Nov 15;370:78-81.
2	Functional analysis of human sodium-phosphate transporter 4 (NPT4/SLC17A3) polymorphisms. J Pharmacol Sci. 2011;115(2):249-53.

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