Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0111 Transporter Info | ||||
| Gene Name | SLC16A7 | ||||
| Protein Name | Monocarboxylate transporter 2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs3763980 | ||||
| Site of GPD | chr12:59779575 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | A>G / A>T | ||||
| Minor Allele Frequency | T=0.2450/1227 (Global) | ||||
| Allele A | Click to Show/Hide the Full List of Affected Drugs: 4 Drugs in Total | ||||
| Methotrexate | Drug Info | Rheumatoid Arthritis | Correlated with the increased drug non-response risk in patients (compare with Allele T) | [ 1] | |
| Methotrexate | N.A. | Testicular Neoplasms | Allele A is associated with increased risk of non-response to methotrexate when treated with methotrexate in children with Arthritis, Juvenile Rheumatoid as compared to allele T. | [ 1] | |
| Methotrexate | N.A. | Testicular Neoplasms | Allele A is associated with decreased response to methotrexate in children with Arthritis, Juvenile Rheumatoid as compared to allele T. | [ 2] | |
| Methotrexate | N.A. | Juvenile Rheumatoid Arthritis | Allele A is associated with increased risk of non-response to methotrexate when treated with methotrexate in children with Arthritis, Juvenile Rheumatoid as compared to allele T. | [ 1] | |
| Genotype AA | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Methotrexate | N.A. | Juvenile Rheumatoid Arthritis | Patients with the AA genotype may have decreased response to methotrexate as compared to TT genotype. Other genetic and clinical factors may also influence a patient's response to methotrexate. | [ 1] | |
| Genotype AT | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Methotrexate | N.A. | Juvenile Rheumatoid Arthritis | Patients with the AA genotype may have decreased response to methotrexate as compared to TT genotype or may have increased response to methotrexate as compared to AA genotype. Other genetic and clinical factors may also influence a patient's response to methotrexate. | [ 1] | |
| Genotype TT | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Methotrexate | N.A. | Juvenile Rheumatoid Arthritis | Patients with the TT genotype may have increased response to methotrexate as compared to AA genotype. Other genetic and clinical factors may also influence a patient's response to methotrexate. | [ 1] | |
| Genetic Polymorphism | rs12231740 | ||||
| Site of GPD | chr12:59710259 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | C>A / C>T | ||||
| Minor Allele Frequency | C=0.7540/1492 (Global) | ||||
| Allele T | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Methotrexate | N.A. | Testicular Neoplasms | Allele T is associated with decreased response to methotrexate in children with Arthritis, Juvenile Rheumatoid as compared to allele C. | [ 2] | |
| References | |||||
| 1 | Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype. Pharmacogenet Genomics. 2010 Nov;20(11):665-76. | ||||
| 2 | Associations between gene polymorphisms and treatment outcomes of methotrexate in patients with juvenile idiopathic arthritis. Pharmacogenomics. 2018 Apr;19(6):529-538. | ||||
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