General Information of Drug Transporter (DT)
DT ID	DTD0100 Transporter Info
Gene Name	SLC16A1
Protein Name	Monocarboxylate transporter 1
Gene ID	6566
UniProt ID	P53985
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs1049434
Site of GPD	chr1:112913924 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>T
Minor Allele Frequency	A=0.3233/1619 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
N.A.	N.A.	Multiple myeloma	Correlated with the progression-free and overall survival in patients (compare with allele A)		[ 1]
Genetic Polymorphism	rs7169
Site of GPD	chr1:112912477 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A
Minor Allele Frequency	G=0.3210/635 (Global)
Genotype GG	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Valproic Acid	N.A.	Hypertension	Genotype GG is associated with increased clinical benefit to valproic acid in children with Epilepsy as compared to genotypes AA + AG.		[ 2]
References
1	Genetic variations in the monocarboxylate transporter genes (SLC16A1, SLC16A3, and SLC16A11) in the Japanese population. Drug Metab Pharmacokinet. 2018 Oct;33(5):215-218.
2	Genetic and non-genetic factors influencing the therapeutic response of valproic acid in pediatric epileptic patients. Per Med. 2025 Feb;22(1):11-19.

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