General Information of Drug Transporter (DT)
DT ID	DTD0051 Transporter Info
Gene Name	ABCB5
Protein Name	ATP-binding cassette sub-family B member 5
Gene ID	340273
UniProt ID	Q2M3G0
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs17143212
Site of GPD	chr7:20643261 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>T
Minor Allele Frequency	T=0.0705/353 (Global)
Genotype CT	Click to Show/Hide the Full List of Affected Drugs:           3 Drugs in Total
Haloperidol	Drug Info	Psychotic Disorders	Correlated with the increased drug toxicity in patients (compare with genotype CC)		[ 1]
Haloperidol	N.A.	Drug Toxicity	Genotype CT is associated with increased Drug Toxicity when treated with haloperidol in people with Psychotic Disorders as compared to genotype CC.		[ 1]
Haloperidol	N.A.	Psychotic Disorder	Genotype CT is associated with increased Drug Toxicity when treated with haloperidol in people with Psychotic Disorders as compared to genotype CC.		[ 1]
Allele T	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Talinolol	N.A.	Hypertriglyceridemia	Allele T is not associated with clearance of talinolol in healthy individuals as compared to allele C.		[ 2]
Genotype CC	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Haloperidol	N.A.	Psychotic Disorder	Patients with the CC genotype and psychotic illnesses may be at a lower risk for haloperidol-induced toxicities as compared to patients with the CT genotype. Other genetic and clinical factors may also influence haloperidol-induced toxicities.		[ 1]
Genotype TT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Haloperidol	N.A.	Psychotic Disorder	No patients with the TT genotype were present, but patients with the CT genotype and psychotic illnesses may be at a greater risk for haloperidol-induced toxicities as compared to patients with the CC genotype. Other genetic and clinical factors may also influence haloperidol-induced toxicities.		[ 1]
Genetic Polymorphism	rs10950831
Site of GPD	chr7:20724751 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>C / G>T
Minor Allele Frequency	G=0.4520/894 (Global)
Allele G	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Cisplatin	N.A.	Ototoxicity	Allele G is not associated with risk of Ototoxicity when treated with cisplatin in people with Neoplasms as compared to allele T.		[ 3]
References
1	The role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humans. PLoS Med. 2015 Feb 3;12(2):e1001782.
2	Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters. Genome Med. 2016 Nov 08;8(1):119.
3	Promoter region variation in NFE2L2 influences susceptibility to ototoxicity in patients exposed to high cumulative doses of cisplatin. Pharmacogenomics J. 2017 Dec;17(6):515-520.

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