General Information of Drug Transporter (DT)
DT ID	DTD0026 Transporter Info
Gene Name	SLC22A11
Protein Name	Organic anion transporter 4
Gene ID	55867
UniProt ID	Q9NSA0
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs11231809
Site of GPD	chr11:64535478 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>A
Minor Allele Frequency	A=0.2802/1403 (Global)
Genotypes AT + TT	Click to Show/Hide the Full List of Affected Drugs:           3 Drugs in Total
Methotrexate	Drug Info	Rheumatoid Arthritis	Correlated with the decreased drug response in patients (compare with genotype AA)		[ 1]
Methotrexate	N.A.	Fever	Genotypes AT + TT are associated with decreased response to methotrexate in people with Arthritis, Rheumatoid as compared to genotype AA.		[ 1]
Methotrexate	N.A.	Rheumatoid Arthritis	Genotypes AT + TT are associated with decreased response to methotrexate in people with Arthritis, Rheumatoid as compared to genotype AA.		[ 1]
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Tenofovir	N.A.	Fever	Allele A is not associated with increased risk of kidney tubular dysfunction when treated with tenofovir in people with HIV Infections as compared to allele T.		[ 2]
Genotype AA	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Methotrexate	N.A.	Rheumatoid Arthritis	Patients with the AA genotype may have increased response to methotrexate in people with Arthritis, Rheumatoid as compared to genotype TT or AT. Other genetic and clinical factors may also influence the response to methotrexate.		[ 1]
Genotype AT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Methotrexate	N.A.	Rheumatoid Arthritis	Patients with the AT genotype may have decreased response to methotrexate in people with Arthritis, Rheumatoid as compared to genotype AA. Other genetic and clinical factors may also influence the response to methotrexate.		[ 1]
Genotype TT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Methotrexate	N.A.	Rheumatoid Arthritis	Patients with the TT genotype may have decreased response to methotrexate in people with Arthritis, Rheumatoid as compared to genotype AA. Other genetic and clinical factors may also influence the response to methotrexate.		[ 1]
Genetic Polymorphism	rs17300741
Site of GPD	chr11:64563990 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>G / A>T
Minor Allele Frequency	A=0.6660/1318 (Global)
Allele G	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Allopurinol	N.A.	Fever	Allele G is not associated with dose of allopurinol in people with Gout as compared to allele A.		[ 3]
Genetic Polymorphism	rs2078267
Site of GPD	chr11:64566642 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>A / C>T
Minor Allele Frequency	C=0.7630/1509 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Furosemide	N.A.	Fever	Allele T is not associated with response to furosemide in healthy individuals as compared to allele C.		[ 4]
References
1	Pharmacogenomics of Methotrexate Membrane Transport Pathway: Can Clinical Response to Methotrexate in Rheumatoid Arthritis Be Predicted? Int J Mol Sci. 2015 Jun 16;16(6):13760-80.
2	Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study. Clin Infect Dis. 2009 Jun 1;48(11):e108-16.
3	The impact of diuretic use and ABCG2 genotype on the predictive performance of a published allopurinol dosing tool. Br J Clin Pharmacol. 2018 May;84(5):937-943.
4	Influence of genetic variants on renal uric acid handling in response to frusemide: an acute intervention study. RMD Open. 2017;3(1):e000424.

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