General Information of Drug Transporter (DT)
DT ID	DTD0025 Transporter Info
Gene Name	SLC22A8
Protein Name	Organic anion transporter 3
Gene ID	9376
UniProt ID	Q8TCC7
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs11568482
Site of GPD	chr11:62995792 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>A
Minor Allele Frequency	A=0.0134/67 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Cefotaxime	Drug Info	Upper Respiratory Tract Infections and Bacterial Meningitis	Correlated with the decreased transport of drug (compare with Allele T)		[ 1]
Cefotaxime	N.A.	Hepatocellular Carcinoma	Allele A is associated with decreased transport of cefotaxime as compared to allele T.		[ 1]
Genotype AT	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Cefotaxime	Drug Info	Healthy Individuals	Correlated with the decreased drug clearance in healthy individuals (compare with Genotype TT)		[ 1]
Cefotaxime	N.A.	Hyperprolactinemia	Genotype AT is associated with decreased clearance of cefotaxime in healthy individuals as compared to genotype TT.		[ 1]
Genotype AA	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Cefotaxime	N.A.	Drug Toxicity	Patients with the AA genotype may have decreased clearance of cefotaxime as compared to patients with the TT genotype. Other genetic and clinical factors may also influence clearance of cefotaxime.		[ 1]
Genotype TT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Cefotaxime	N.A.	Drug Toxicity	Patients with the TT genotype may have increased clearance of cefotaxime as compared to patients with the AA or AT genotype. Other genetic and clinical factors may also influence clearance of cefotaxime.		[ 1]
Genetic Polymorphism	rs2276299
Site of GPD	chr11:62998959 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>G / A>T
Minor Allele Frequency	A=0.8180/1618 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Risperidone	N.A.	Hyperprolactinemia	Allele A is not associated with risk of Hyperprolactinemia when treated with risperidone in children with Autism Spectrum Disorder as compared to allele T.		[ 2]
References
1	Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). J Pharm Sci. 2013 Sep;102(9):3451-7.
2	UGT1A1 polymorphisms associated with prolactin response in risperidone-treated children and adolescents with autism spectrum disorder. Pharmacogenomics J. 2018 Dec;18(6):740-748.

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