General Information of Drug Transporter (DT)
DT ID	DTD0019 Transporter Info
Gene Name	SLC10A1
Protein Name	Sodium/taurocholate cotransporting polypeptide
Gene ID	6554
UniProt ID	Q14973
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs56903885
Site of GPD	chr14:69776372 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>T
Minor Allele Frequency	G=0.9970/1973 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Rosuvastatin	N.A.	Colorectal Neoplasms	Allele T is associated with decreased exposure to rosuvastatin in healthy individuals as compared to allele G.		[ 1]
Genetic Polymorphism	rs2296651
Site of GPD	chr14:69778476 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A
Minor Allele Frequency	G=0.9870/1953 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Pravastatin	N.A.	Colorectal Neoplasms	Allele A is associated with increased clearance of pravastatin in healthy individuals as compared to allele G.		[ 2]
References
1	An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C. Pharmacogenomics J. 2019 Jun;19(3):240-248.
2	Mixed effects of OATP1B1, BCRP and NTCP polymorphisms on the population pharmacokinetics of pravastatin in healthy volunteers. Xenobiotica. 2016 Sep;46(9):841-9.

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