Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0009 Transporter Info | ||||
| Gene Name | SLC22A3 | ||||
| Protein Name | Organic cation transporter 3 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs2076828 | ||||
| Site of GPD | chr6:160451754 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | C>G | ||||
| Minor Allele Frequency | G=0.4866/2437 (Global) | ||||
| Allele G | Click to Show/Hide the Full List of Affected Drugs: 3 Drugs in Total | ||||
| Metformin | Drug Info | Healthy Individuals | Correlated with the decreased drug response in healthy individuals (compare with Allele C) | [ 1] | |
| Metformin | Drug Info | Diabetes Mellitus | Correlated with the decreased expression of SLC22A3 (compare with Allele C) | [ 1] | |
| Metformin | N.A. | Non-small Cell Lung Carcinoma | Allele G is associated with decreased response to metformin in healthy individuals as compared to allele C. | [ 1] | |
| Genotype CC | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Metformin | N.A. | Polycystic Ovary Syndrome | Patients with the CC genotype may have a decreased response to metformin as compared to patients with the CG and GG genotype. Other genetic and clinical factors may also influence response to metformin. | [ 1] | |
| Genotype CG | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Metformin | N.A. | Polycystic Ovary Syndrome | Patients with the CG genotype may have a decreased response to metformin as compared to patients with the GG genotype and an increased response to metformin as compared to patients with the CC genotype. Other genetic and clinical factors may also influence response to metformin. | [ 1] | |
| Genotype GG | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Metformin | N.A. | Polycystic Ovary Syndrome | Patients with the GG genotype may have a decreased response to metformin as compared to patients with the CG and CC genotype. Other genetic and clinical factors may also influence response to metformin. | [ 1] | |
| Genetic Polymorphism | rs8187725 | ||||
| Site of GPD | chr6:160437122 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | C>A / C>T | ||||
| Allele T | Click to Show/Hide the Full List of Affected Drugs: 4 Drugs in Total | ||||
| Metformin | Drug Info | Diabetes Mellitus | Correlated with the decreased drug metabolism (compare with allele C) | [ 2] | |
| Catecholamines | N.A. | Non-small Cell Lung Carcinoma | Allele T is associated with decreased metabolism of catecholamines and metformin as compared to allele C. | [ 2] | |
| Metformin | N.A. | Non-small Cell Lung Carcinoma | Allele T is associated with decreased metabolism of catecholamines and metformin as compared to allele C. | [ 2] | |
| Catecholamines | N.A. | . | Correlated with the decreased drug metabolism (compare with allele C) | [ 2] | |
| Genotype CC | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Catecholamines | N.A. | Polycystic Ovary Syndrome | Cells with the CC genotype may have increased uptake of catecholamines or metformin as compared to those with the TT genotype. Other factors may also influence uptake of these drugs. | [ 2] | |
| Metformin | N.A. | Polycystic Ovary Syndrome | Cells with the CC genotype may have increased uptake of catecholamines or metformin as compared to those with the TT genotype. Other factors may also influence uptake of these drugs. | [ 2] | |
| Genotype CT | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Catecholamines | N.A. | Polycystic Ovary Syndrome | Cells with the CT genotype may have increased uptake of catecholamines or metformin as compared to those with the TT genotype, or decreased uptake as compared to those with the CC genotype. Other factors may also influence uptake of these drugs. | [ 2] | |
| Metformin | N.A. | Polycystic Ovary Syndrome | Cells with the CT genotype may have increased uptake of catecholamines or metformin as compared to those with the TT genotype, or decreased uptake as compared to those with the CC genotype. Other factors may also influence uptake of these drugs. | [ 2] | |
| Genotype TT | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Catecholamines | N.A. | Polycystic Ovary Syndrome | Cells with the TT genotype may have decreased uptake of catecholamines or metformin as compared to those with the CC genotype. Other factors may also influence uptake of these drugs. | [ 2] | |
| Metformin | N.A. | Polycystic Ovary Syndrome | Cells with the TT genotype may have decreased uptake of catecholamines or metformin as compared to those with the CC genotype. Other factors may also influence uptake of these drugs. | [ 2] | |
| Genetic Polymorphism | rs3127602 | ||||
| Site of GPD | chr6:160471209 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | C>G / C>T | ||||
| Minor Allele Frequency | C=0.7670/1517 (Global) | ||||
| Allele T | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Metformin | N.A. | Non-small Cell Lung Carcinoma | Allele T is associated with increased response to metformin in people with Diabetes Mellitus, Type 2 as compared to allele C. | [ 3] | |
| References | |||||
| 1 | Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin. Mol Pharmacol. 2015 Jul;88(1):75-83. | ||||
| 2 | Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin. Pharmacogenet Genomics. 2010 Nov;20(11):687-99. | ||||
| 3 | Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics. Stud Health Technol Inform. 2015;210:914-8. | ||||
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