General Information of Drug Transporter (DT)
DT ID DTD0489 Transporter Info
Gene Name SLC9A5
Transporter Name Sodium/hydrogen exchanger 5
Gene ID
6553
UniProt ID
Q14940
Epigenetic Regulations of This DT (EGR)

Methylation

  Colon cancer

           1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC9A5 in colon adenocarcinoma [ 1 ]

Location

TSS1500 (cg14439761)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.98E+00 Statistic Test p-value:8.43E-08; Z-score:2.66E+00

Methylation in Case

5.36E-01 (Median) Methylation in Control 2.71E-01 (Median)

Studied Phenotype

Colon cancer[ ICD-11:2B90]

Experimental Material

Patient tissue samples

  Pancretic ductal adenocarcinoma

           2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC9A5 in pancretic ductal adenocarcinoma [ 2 ]

Location

TSS200 (cg01233487)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.19E+00 Statistic Test p-value:7.49E-06; Z-score:-1.20E+00

Methylation in Case

4.92E-01 (Median) Methylation in Control 5.85E-01 (Median)

Studied Phenotype

Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC9A5 in pancretic ductal adenocarcinoma [ 2 ]

Location

Body (cg26877715)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:3.78E+00 Statistic Test p-value:5.49E-45; Z-score:1.54E+01

Methylation in Case

3.32E-01 (Median) Methylation in Control 8.78E-02 (Median)

Studied Phenotype

Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

Patient tissue samples

  Breast cancer

           3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC9A5 in breast cancer [ 3 ]

Location

1stExon (cg23357854)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.17E+00 Statistic Test p-value:3.17E-04; Z-score:9.44E-01

Methylation in Case

1.09E-01 (Median) Methylation in Control 9.37E-02 (Median)

Studied Phenotype

Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC9A5 in breast cancer [ 3 ]

Location

Body (cg08638180)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.42E+00 Statistic Test p-value:6.29E-17; Z-score:3.98E+00

Methylation in Case

5.10E-01 (Median) Methylation in Control 3.59E-01 (Median)

Studied Phenotype

Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC9A5 in breast cancer [ 3 ]

Location

Body (cg10503473)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.02E+00 Statistic Test p-value:6.15E-08; Z-score:-1.86E+00

Methylation in Case

9.45E-01 (Median) Methylation in Control 9.68E-01 (Median)

Studied Phenotype

Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

Patient tissue samples

  Colorectal cancer

           6 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC9A5 in colorectal cancer [ 4 ]

Location

1stExon (cg23357854)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.19E+00 Statistic Test p-value:5.90E-05; Z-score:1.12E+00

Methylation in Case

1.49E-01 (Median) Methylation in Control 1.26E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC9A5 in colorectal cancer [ 4 ]

Location

Body (cg05256656)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.01E+00 Statistic Test p-value:2.73E-06; Z-score:-1.02E+00

Methylation in Case

9.12E-01 (Median) Methylation in Control 9.22E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC9A5 in colorectal cancer [ 4 ]

Location

Body (cg09407223)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.24E+00 Statistic Test p-value:1.17E-05; Z-score:-1.35E+00

Methylation in Case

5.30E-01 (Median) Methylation in Control 6.59E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon4

Methylation of SLC9A5 in colorectal cancer [ 4 ]

Location

Body (cg08638180)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.11E+00 Statistic Test p-value:2.05E-05; Z-score:1.04E+00

Methylation in Case

6.95E-01 (Median) Methylation in Control 6.24E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon5

Methylation of SLC9A5 in colorectal cancer [ 4 ]

Location

Body (cg10503473)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.00E+00 Statistic Test p-value:6.36E-03; Z-score:-1.95E-01

Methylation in Case

9.64E-01 (Median) Methylation in Control 9.65E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon6

Methylation of SLC9A5 in colorectal cancer [ 4 ]

Location

3'UTR (cg06566678)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.01E+00 Statistic Test p-value:3.38E-04; Z-score:-7.10E-01

Methylation in Case

9.05E-01 (Median) Methylation in Control 9.12E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Hepatocellular carcinoma

           9 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC9A5 in hepatocellular carcinoma [ 5 ]

Location

1stExon (cg23357854)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.39E+00 Statistic Test p-value:5.50E-06; Z-score:1.62E+00

Methylation in Case

1.75E-01 (Median) Methylation in Control 1.26E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC9A5 in hepatocellular carcinoma [ 5 ]

Location

1stExon (cg08025511)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.14E+00 Statistic Test p-value:1.40E-04; Z-score:8.85E-01

Methylation in Case

8.16E-02 (Median) Methylation in Control 7.14E-02 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC9A5 in hepatocellular carcinoma [ 5 ]

Location

Body (cg04218022)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.59E+00 Statistic Test p-value:2.26E-18; Z-score:-4.74E+00

Methylation in Case

4.55E-01 (Median) Methylation in Control 7.24E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon4

Methylation of SLC9A5 in hepatocellular carcinoma [ 5 ]

Location

Body (cg05256656)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.12E+00 Statistic Test p-value:2.05E-09; Z-score:-2.20E+00

Methylation in Case

7.03E-01 (Median) Methylation in Control 7.87E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon5

Methylation of SLC9A5 in hepatocellular carcinoma [ 5 ]

Location

Body (cg08878263)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.43E+00 Statistic Test p-value:2.93E-09; Z-score:-2.06E+00

Methylation in Case

4.22E-01 (Median) Methylation in Control 6.02E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon6

Methylation of SLC9A5 in hepatocellular carcinoma [ 5 ]

Location

Body (cg09407223)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.19E+00 Statistic Test p-value:2.79E-08; Z-score:-1.78E+00

Methylation in Case

5.70E-01 (Median) Methylation in Control 6.79E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon7

Methylation of SLC9A5 in hepatocellular carcinoma [ 5 ]

Location

Body (cg07983330)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.04E+00 Statistic Test p-value:3.32E-06; Z-score:-6.32E-01

Methylation in Case

8.01E-01 (Median) Methylation in Control 8.36E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon8

Methylation of SLC9A5 in hepatocellular carcinoma [ 5 ]

Location

Body (cg08638180)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.10E+00 Statistic Test p-value:9.16E-03; Z-score:8.53E-01

Methylation in Case

4.53E-01 (Median) Methylation in Control 4.13E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon9

Methylation of SLC9A5 in hepatocellular carcinoma [ 5 ]

Location

3'UTR (cg06566678)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.07E+00 Statistic Test p-value:6.03E-08; Z-score:-1.72E+00

Methylation in Case

8.03E-01 (Median) Methylation in Control 8.58E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Papillary thyroid cancer

           5 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC9A5 in papillary thyroid cancer [ 6 ]

Location

1stExon (cg23357854)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.12E+00 Statistic Test p-value:6.58E-04; Z-score:-7.99E-01

Methylation in Case

9.08E-02 (Median) Methylation in Control 1.02E-01 (Median)

Studied Phenotype

Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC9A5 in papillary thyroid cancer [ 6 ]

Location

Body (cg09407223)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.15E+00 Statistic Test p-value:2.22E-11; Z-score:-2.36E+00

Methylation in Case

4.59E-01 (Median) Methylation in Control 5.30E-01 (Median)

Studied Phenotype

Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC9A5 in papillary thyroid cancer [ 6 ]

Location

Body (cg08638180)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.07E+00 Statistic Test p-value:2.14E-03; Z-score:3.98E-01

Methylation in Case

3.48E-01 (Median) Methylation in Control 3.24E-01 (Median)

Studied Phenotype

Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon4

Methylation of SLC9A5 in papillary thyroid cancer [ 6 ]

Location

Body (cg05256656)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.02E+00 Statistic Test p-value:7.39E-03; Z-score:-7.77E-01

Methylation in Case

8.48E-01 (Median) Methylation in Control 8.66E-01 (Median)

Studied Phenotype

Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon5

Methylation of SLC9A5 in papillary thyroid cancer [ 6 ]

Location

3'UTR (cg06566678)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.03E+00 Statistic Test p-value:3.18E-06; Z-score:1.09E+00

Methylation in Case

9.29E-01 (Median) Methylation in Control 9.01E-01 (Median)

Studied Phenotype

Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

Patient tissue samples

  Bladder cancer

           7 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC9A5 in bladder cancer [ 7 ]

Location

Body (cg09407223)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-2.05E+00 Statistic Test p-value:4.03E-08; Z-score:-8.06E+00

Methylation in Case

3.15E-01 (Median) Methylation in Control 6.46E-01 (Median)

Studied Phenotype

Bladder cancer[ ICD-11:2C94]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC9A5 in bladder cancer [ 7 ]

Location

Body (cg08878263)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-2.00E+00 Statistic Test p-value:1.08E-07; Z-score:-6.98E+00

Methylation in Case

3.16E-01 (Median) Methylation in Control 6.31E-01 (Median)

Studied Phenotype

Bladder cancer[ ICD-11:2C94]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC9A5 in bladder cancer [ 7 ]

Location

Body (cg05256656)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.23E+00 Statistic Test p-value:2.91E-07; Z-score:-1.23E+01

Methylation in Case

6.31E-01 (Median) Methylation in Control 7.77E-01 (Median)

Studied Phenotype

Bladder cancer[ ICD-11:2C94]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon4

Methylation of SLC9A5 in bladder cancer [ 7 ]

Location

Body (cg10503473)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.11E+00 Statistic Test p-value:2.34E-05; Z-score:-1.48E+01

Methylation in Case

8.67E-01 (Median) Methylation in Control 9.61E-01 (Median)

Studied Phenotype

Bladder cancer[ ICD-11:2C94]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon5

Methylation of SLC9A5 in bladder cancer [ 7 ]

Location

Body (cg07983330)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.10E+00 Statistic Test p-value:9.55E-05; Z-score:-4.06E+00

Methylation in Case

7.90E-01 (Median) Methylation in Control 8.69E-01 (Median)

Studied Phenotype

Bladder cancer[ ICD-11:2C94]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon6

Methylation of SLC9A5 in bladder cancer [ 7 ]

Location

Body (cg08638180)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.17E+00 Statistic Test p-value:2.33E-02; Z-score:1.89E+00

Methylation in Case

3.72E-01 (Median) Methylation in Control 3.19E-01 (Median)

Studied Phenotype

Bladder cancer[ ICD-11:2C94]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon7

Methylation of SLC9A5 in bladder cancer [ 7 ]

Location

3'UTR (cg06566678)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.15E+00 Statistic Test p-value:3.97E-05; Z-score:-1.05E+01

Methylation in Case

6.75E-01 (Median) Methylation in Control 7.73E-01 (Median)

Studied Phenotype

Bladder cancer[ ICD-11:2C94]

Experimental Material

Patient tissue samples

  Renal cell carcinoma

           1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC9A5 in clear cell renal cell carcinoma [ 8 ]

Location

Body (cg08638180)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.44E+00 Statistic Test p-value:1.78E-09; Z-score:3.56E+00

Methylation in Case

5.26E-01 (Median) Methylation in Control 3.65E-01 (Median)

Studied Phenotype

Renal cell carcinoma[ ICD-11:2C90]

Experimental Material

Patient tissue samples

  Lung adenocarcinoma

           1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC9A5 in lung adenocarcinoma [ 9 ]

Location

Body (cg08638180)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.16E+00 Statistic Test p-value:3.91E-03; Z-score:2.23E+00

Methylation in Case

5.89E-01 (Median) Methylation in Control 5.07E-01 (Median)

Studied Phenotype

Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

Patient tissue samples

  Prostate cancer

           1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC9A5 in prostate cancer [ 10 ]

Location

Body (cg02996583)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.09E+00 Statistic Test p-value:6.42E-03; Z-score:2.77E+00

Methylation in Case

8.86E-01 (Median) Methylation in Control 8.16E-01 (Median)

Studied Phenotype

Prostate cancer[ ICD-11:2C82]

Experimental Material

Patient tissue samples

microRNA

  Unclear Phenotype

           1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

miR-192 directly targets SLC9A5 [ 11 ]

Epigenetic Type

microRNA Experiment Method Microarray

miRNA Stemloop ID

miR-192 miRNA Mature ID miR-192-5p

miRNA Sequence

CUGACCUAUGAAUUGACAGCC

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human
References
1 Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips. Epigenetics. 2013 Sep;8(9):921-34.
2 Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer. 2014 Sep 1;135(5):1110-8.
3 Genome-wide Scan for Methylation Profiles in Breast Cancer
4 Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8.
5 Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 Jan;8(1):34-43.
6 Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.
7 DNA Methylation Dynamics in Urological Tumors.
8 A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma. Nat Commun. 2015 Oct 30;6:8699.
9 DNA methylation analysis of lung adenocarcinoma and adjacent non-tumor tissues
10 Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array. BMC Genomics. 2014 Jan 22;15:51.
11 Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215. Cancer Res. 2008 Dec 15;68(24):10105-12.

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