General Information of Drug Transporter (DT)
DT ID DTD0164 Transporter Info
Gene Name SLC24A3
Transporter Name Sodium/potassium/calcium exchanger 3
Gene ID
57419
UniProt ID
Q9HC58
Epigenetic Regulations of This DT (EGR)

Methylation

  Colon cancer

           6 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC24A3 in colon adenocarcinoma [ 1 ]

Location

5'UTR (cg00350003)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:4.63E+00 Statistic Test p-value:3.91E-05; Z-score:1.09E+01

Methylation in Case

2.53E-01 (Median) Methylation in Control 5.47E-02 (Median)

Studied Phenotype

Colon cancer[ ICD-11:2B90]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC24A3 in colon adenocarcinoma [ 1 ]

Location

TSS200 (cg19980771)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.22E+00 Statistic Test p-value:5.62E-06; Z-score:1.36E+00

Methylation in Case

8.35E-01 (Median) Methylation in Control 6.83E-01 (Median)

Studied Phenotype

Colon cancer[ ICD-11:2B90]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC24A3 in colon adenocarcinoma [ 1 ]

Location

Body (cg07262873)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.19E+00 Statistic Test p-value:1.39E-04; Z-score:1.33E+00

Methylation in Case

4.82E-01 (Median) Methylation in Control 4.06E-01 (Median)

Studied Phenotype

Colon cancer[ ICD-11:2B90]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon4

Methylation of SLC24A3 in colon adenocarcinoma [ 1 ]

Location

Body (cg13806356)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.15E+00 Statistic Test p-value:3.97E-04; Z-score:-1.21E+00

Methylation in Case

4.37E-01 (Median) Methylation in Control 5.02E-01 (Median)

Studied Phenotype

Colon cancer[ ICD-11:2B90]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon5

Methylation of SLC24A3 in colon adenocarcinoma [ 1 ]

Location

Body (cg08848753)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.01E+00 Statistic Test p-value:6.87E-04; Z-score:-1.42E+00

Methylation in Case

9.50E-01 (Median) Methylation in Control 9.60E-01 (Median)

Studied Phenotype

Colon cancer[ ICD-11:2B90]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon6

Methylation of SLC24A3 in colon adenocarcinoma [ 1 ]

Location

Body (cg27649194)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.07E+00 Statistic Test p-value:2.43E-03; Z-score:7.80E-01

Methylation in Case

5.84E-01 (Median) Methylation in Control 5.46E-01 (Median)

Studied Phenotype

Colon cancer[ ICD-11:2B90]

Experimental Material

Patient tissue samples

  Bladder cancer

           6 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC24A3 in bladder cancer [ 2 ]

Location

TSS1500 (cg01352551)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.29E+00 Statistic Test p-value:2.90E-05; Z-score:-3.74E+00

Methylation in Case

6.09E-01 (Median) Methylation in Control 7.83E-01 (Median)

Studied Phenotype

Bladder cancer[ ICD-11:2C94]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC24A3 in bladder cancer [ 2 ]

Location

TSS1500 (cg11755796)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.17E+00 Statistic Test p-value:3.24E-02; Z-score:2.35E+00

Methylation in Case

1.39E-01 (Median) Methylation in Control 1.19E-01 (Median)

Studied Phenotype

Bladder cancer[ ICD-11:2C94]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC24A3 in bladder cancer [ 2 ]

Location

Body (cg16172619)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.39E+00 Statistic Test p-value:3.97E-06; Z-score:-1.81E+01

Methylation in Case

4.89E-01 (Median) Methylation in Control 6.79E-01 (Median)

Studied Phenotype

Bladder cancer[ ICD-11:2C94]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon4

Methylation of SLC24A3 in bladder cancer [ 2 ]

Location

Body (cg13805533)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.23E+00 Statistic Test p-value:9.99E-06; Z-score:-1.35E+01

Methylation in Case

7.05E-01 (Median) Methylation in Control 8.66E-01 (Median)

Studied Phenotype

Bladder cancer[ ICD-11:2C94]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon5

Methylation of SLC24A3 in bladder cancer [ 2 ]

Location

Body (cg02718002)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.06E+00 Statistic Test p-value:3.82E-03; Z-score:-3.60E+00

Methylation in Case

8.62E-01 (Median) Methylation in Control 9.13E-01 (Median)

Studied Phenotype

Bladder cancer[ ICD-11:2C94]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon6

Methylation of SLC24A3 in bladder cancer [ 2 ]

Location

3'UTR (cg19977363)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.06E+00 Statistic Test p-value:1.83E-04; Z-score:-2.66E+00

Methylation in Case

8.33E-01 (Median) Methylation in Control 8.84E-01 (Median)

Studied Phenotype

Bladder cancer[ ICD-11:2C94]

Experimental Material

Patient tissue samples

  Breast cancer

           7 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC24A3 in breast cancer [ 3 ]

Location

TSS1500 (cg11755796)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.16E+00 Statistic Test p-value:1.23E-03; Z-score:6.28E-01

Methylation in Case

1.02E-01 (Median) Methylation in Control 8.83E-02 (Median)

Studied Phenotype

Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC24A3 in breast cancer [ 3 ]

Location

TSS1500 (cg01557989)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.24E+00 Statistic Test p-value:1.27E-03; Z-score:7.95E-01

Methylation in Case

6.76E-02 (Median) Methylation in Control 5.46E-02 (Median)

Studied Phenotype

Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC24A3 in breast cancer [ 3 ]

Location

Body (cg20194982)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.09E+00 Statistic Test p-value:2.53E-12; Z-score:1.54E+00

Methylation in Case

8.56E-01 (Median) Methylation in Control 7.85E-01 (Median)

Studied Phenotype

Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon4

Methylation of SLC24A3 in breast cancer [ 3 ]

Location

Body (cg20244340)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.22E+00 Statistic Test p-value:2.65E-09; Z-score:-1.50E+00

Methylation in Case

2.63E-01 (Median) Methylation in Control 3.22E-01 (Median)

Studied Phenotype

Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon5

Methylation of SLC24A3 in breast cancer [ 3 ]

Location

Body (cg02718002)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.01E+00 Statistic Test p-value:1.05E-05; Z-score:-9.60E-01

Methylation in Case

8.83E-01 (Median) Methylation in Control 8.95E-01 (Median)

Studied Phenotype

Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon6

Methylation of SLC24A3 in breast cancer [ 3 ]

Location

Body (cg13805533)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.23E+00 Statistic Test p-value:1.96E-03; Z-score:-9.89E-01

Methylation in Case

7.28E-01 (Median) Methylation in Control 8.95E-01 (Median)

Studied Phenotype

Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon7

Methylation of SLC24A3 in breast cancer [ 3 ]

Location

3'UTR (cg19977363)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.01E+00 Statistic Test p-value:2.74E-03; Z-score:-6.00E-01

Methylation in Case

8.75E-01 (Median) Methylation in Control 8.88E-01 (Median)

Studied Phenotype

Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

Patient tissue samples

  Renal cell carcinoma

           7 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC24A3 in clear cell renal cell carcinoma [ 4 ]

Location

TSS1500 (cg27382790)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.54E+00 Statistic Test p-value:7.32E-06; Z-score:1.50E+00

Methylation in Case

1.07E-01 (Median) Methylation in Control 6.92E-02 (Median)

Studied Phenotype

Renal cell carcinoma[ ICD-11:2C90]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC24A3 in clear cell renal cell carcinoma [ 4 ]

Location

TSS1500 (cg11755796)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.33E+00 Statistic Test p-value:6.72E-04; Z-score:1.31E+00

Methylation in Case

7.65E-02 (Median) Methylation in Control 5.74E-02 (Median)

Studied Phenotype

Renal cell carcinoma[ ICD-11:2C90]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC24A3 in clear cell renal cell carcinoma [ 4 ]

Location

TSS1500 (cg01557989)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.51E+00 Statistic Test p-value:4.37E-03; Z-score:1.21E+00

Methylation in Case

3.27E-02 (Median) Methylation in Control 2.16E-02 (Median)

Studied Phenotype

Renal cell carcinoma[ ICD-11:2C90]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon4

Methylation of SLC24A3 in clear cell renal cell carcinoma [ 4 ]

Location

TSS1500 (cg01352551)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.01E+00 Statistic Test p-value:1.70E-02; Z-score:4.05E-01

Methylation in Case

9.03E-01 (Median) Methylation in Control 8.93E-01 (Median)

Studied Phenotype

Renal cell carcinoma[ ICD-11:2C90]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon5

Methylation of SLC24A3 in clear cell renal cell carcinoma [ 4 ]

Location

TSS1500 (cg15501281)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.06E+00 Statistic Test p-value:4.40E-02; Z-score:1.30E-01

Methylation in Case

1.81E-02 (Median) Methylation in Control 1.71E-02 (Median)

Studied Phenotype

Renal cell carcinoma[ ICD-11:2C90]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon6

Methylation of SLC24A3 in clear cell renal cell carcinoma [ 4 ]

Location

1stExon (cg14887315)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.14E+00 Statistic Test p-value:2.28E-03; Z-score:1.04E+00

Methylation in Case

1.61E-02 (Median) Methylation in Control 1.41E-02 (Median)

Studied Phenotype

Renal cell carcinoma[ ICD-11:2C90]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon7

Methylation of SLC24A3 in clear cell renal cell carcinoma [ 4 ]

Location

Body (cg00888479)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.39E+00 Statistic Test p-value:1.28E-04; Z-score:1.52E+00

Methylation in Case

1.10E-01 (Median) Methylation in Control 7.92E-02 (Median)

Studied Phenotype

Renal cell carcinoma[ ICD-11:2C90]

Experimental Material

Patient tissue samples

  Colorectal cancer

         12 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC24A3 in colorectal cancer [ 5 ]

Location

TSS1500 (cg11755796)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:2.22E+00 Statistic Test p-value:7.78E-09; Z-score:4.08E+00

Methylation in Case

1.47E-01 (Median) Methylation in Control 6.64E-02 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC24A3 in colorectal cancer [ 5 ]

Location

TSS1500 (cg27382790)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.24E+00 Statistic Test p-value:1.25E-06; Z-score:1.55E+00

Methylation in Case

1.72E-01 (Median) Methylation in Control 1.39E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC24A3 in colorectal cancer [ 5 ]

Location

TSS1500 (cg01557989)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.33E+00 Statistic Test p-value:2.23E-06; Z-score:1.47E+00

Methylation in Case

1.20E-01 (Median) Methylation in Control 9.05E-02 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon4

Methylation of SLC24A3 in colorectal cancer [ 5 ]

Location

TSS1500 (cg15501281)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.05E+00 Statistic Test p-value:4.14E-05; Z-score:2.26E-01

Methylation in Case

2.23E-02 (Median) Methylation in Control 2.11E-02 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon5

Methylation of SLC24A3 in colorectal cancer [ 5 ]

Location

1stExon (cg14887315)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.26E+00 Statistic Test p-value:7.99E-04; Z-score:9.21E-01

Methylation in Case

1.59E-02 (Median) Methylation in Control 1.26E-02 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon6

Methylation of SLC24A3 in colorectal cancer [ 5 ]

Location

Body (cg16172619)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.13E+00 Statistic Test p-value:2.10E-09; Z-score:-3.13E+00

Methylation in Case

7.51E-01 (Median) Methylation in Control 8.50E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon7

Methylation of SLC24A3 in colorectal cancer [ 5 ]

Location

Body (cg00888479)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.35E+00 Statistic Test p-value:2.67E-07; Z-score:2.10E+00

Methylation in Case

2.17E-01 (Median) Methylation in Control 1.61E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon8

Methylation of SLC24A3 in colorectal cancer [ 5 ]

Location

Body (cg20244340)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.27E+00 Statistic Test p-value:1.81E-04; Z-score:1.41E+00

Methylation in Case

3.64E-01 (Median) Methylation in Control 2.87E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon9

Methylation of SLC24A3 in colorectal cancer [ 5 ]

Location

Body (cg20194982)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.00E+00 Statistic Test p-value:1.27E-02; Z-score:-1.69E-01

Methylation in Case

9.46E-01 (Median) Methylation in Control 9.48E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon10

Methylation of SLC24A3 in colorectal cancer [ 5 ]

Location

Body (cg02718002)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.00E+00 Statistic Test p-value:1.97E-02; Z-score:-4.70E-01

Methylation in Case

9.47E-01 (Median) Methylation in Control 9.50E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon11

Methylation of SLC24A3 in colorectal cancer [ 5 ]

Location

Body (cg13805533)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.01E+00 Statistic Test p-value:4.69E-02; Z-score:-3.21E-01

Methylation in Case

8.71E-01 (Median) Methylation in Control 8.77E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon12

Methylation of SLC24A3 in colorectal cancer [ 5 ]

Location

3'UTR (cg19977363)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.00E+00 Statistic Test p-value:1.56E-02; Z-score:6.50E-03

Methylation in Case

9.07E-01 (Median) Methylation in Control 9.07E-01 (Median)

Studied Phenotype

Colorectal cancer[ ICD-11:2B91]

Experimental Material

Patient tissue samples

  Hepatocellular carcinoma

         12 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC24A3 in hepatocellular carcinoma [ 6 ]

Location

TSS1500 (cg00315391)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:2.55E+00 Statistic Test p-value:4.07E-11; Z-score:4.75E+00

Methylation in Case

2.26E-01 (Median) Methylation in Control 8.88E-02 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC24A3 in hepatocellular carcinoma [ 6 ]

Location

TSS1500 (cg27382790)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.70E+00 Statistic Test p-value:2.40E-08; Z-score:3.24E+00

Methylation in Case

2.51E-01 (Median) Methylation in Control 1.48E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC24A3 in hepatocellular carcinoma [ 6 ]

Location

TSS1500 (cg15501281)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:3.37E+00 Statistic Test p-value:3.52E-08; Z-score:2.26E+00

Methylation in Case

1.51E-01 (Median) Methylation in Control 4.50E-02 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon4

Methylation of SLC24A3 in hepatocellular carcinoma [ 6 ]

Location

TSS1500 (cg01557989)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.44E+00 Statistic Test p-value:1.31E-07; Z-score:2.48E+00

Methylation in Case

1.39E-01 (Median) Methylation in Control 9.66E-02 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon5

Methylation of SLC24A3 in hepatocellular carcinoma [ 6 ]

Location

TSS1500 (cg11755796)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.03E+00 Statistic Test p-value:3.96E-05; Z-score:1.79E-01

Methylation in Case

1.33E-01 (Median) Methylation in Control 1.29E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon6

Methylation of SLC24A3 in hepatocellular carcinoma [ 6 ]

Location

TSS200 (cg24890054)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:4.80E+00 Statistic Test p-value:1.15E-11; Z-score:5.78E+00

Methylation in Case

3.65E-01 (Median) Methylation in Control 7.60E-02 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon7

Methylation of SLC24A3 in hepatocellular carcinoma [ 6 ]

Location

1stExon (cg14887315)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.10E+00 Statistic Test p-value:3.94E-03; Z-score:3.06E-01

Methylation in Case

3.53E-02 (Median) Methylation in Control 3.21E-02 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon8

Methylation of SLC24A3 in hepatocellular carcinoma [ 6 ]

Location

Body (cg11249835)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.23E+00 Statistic Test p-value:2.05E-12; Z-score:-6.22E+00

Methylation in Case

6.96E-01 (Median) Methylation in Control 8.59E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon9

Methylation of SLC24A3 in hepatocellular carcinoma [ 6 ]

Location

Body (cg00888479)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.54E+00 Statistic Test p-value:5.08E-07; Z-score:3.79E+00

Methylation in Case

2.38E-01 (Median) Methylation in Control 1.55E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon10

Methylation of SLC24A3 in hepatocellular carcinoma [ 6 ]

Location

Body (cg20244340)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.32E+00 Statistic Test p-value:1.96E-02; Z-score:-1.72E+00

Methylation in Case

2.12E-01 (Median) Methylation in Control 2.79E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon11

Methylation of SLC24A3 in hepatocellular carcinoma [ 6 ]

Location

3'UTR (cg14491707)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.41E+00 Statistic Test p-value:9.62E-19; Z-score:-3.83E+00

Methylation in Case

3.21E-01 (Median) Methylation in Control 4.52E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon12

Methylation of SLC24A3 in hepatocellular carcinoma [ 6 ]

Location

3'UTR (cg00079485)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.22E+00 Statistic Test p-value:1.90E-11; Z-score:-4.79E+00

Methylation in Case

6.16E-01 (Median) Methylation in Control 7.50E-01 (Median)

Studied Phenotype

Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

Patient tissue samples

  Lung adenocarcinoma

           5 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC24A3 in lung adenocarcinoma [ 7 ]

Location

TSS1500 (cg01557989)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.25E+00 Statistic Test p-value:2.39E-02; Z-score:2.06E+00

Methylation in Case

1.12E-01 (Median) Methylation in Control 8.94E-02 (Median)

Studied Phenotype

Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC24A3 in lung adenocarcinoma [ 7 ]

Location

TSS1500 (cg15501281)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.91E+00 Statistic Test p-value:3.32E-02; Z-score:4.12E+00

Methylation in Case

7.11E-02 (Median) Methylation in Control 3.73E-02 (Median)

Studied Phenotype

Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC24A3 in lung adenocarcinoma [ 7 ]

Location

Body (cg13805533)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.12E+00 Statistic Test p-value:3.22E-03; Z-score:-3.10E+00

Methylation in Case

7.68E-01 (Median) Methylation in Control 8.58E-01 (Median)

Studied Phenotype

Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon4

Methylation of SLC24A3 in lung adenocarcinoma [ 7 ]

Location

Body (cg16172619)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.07E+00 Statistic Test p-value:2.87E-02; Z-score:1.24E+00

Methylation in Case

7.35E-01 (Median) Methylation in Control 6.90E-01 (Median)

Studied Phenotype

Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon5

Methylation of SLC24A3 in lung adenocarcinoma [ 7 ]

Location

Body (cg00888479)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.34E+00 Statistic Test p-value:3.06E-02; Z-score:2.51E+00

Methylation in Case

2.37E-01 (Median) Methylation in Control 1.78E-01 (Median)

Studied Phenotype

Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

Patient tissue samples

  Prostate cancer

           3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC24A3 in prostate cancer [ 8 ]

Location

TSS1500 (cg01826863)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.17E+00 Statistic Test p-value:1.52E-02; Z-score:2.21E+00

Methylation in Case

1.84E-01 (Median) Methylation in Control 1.57E-01 (Median)

Studied Phenotype

Prostate cancer[ ICD-11:2C82]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC24A3 in prostate cancer [ 8 ]

Location

TSS1500 (cg05895666)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.66E+00 Statistic Test p-value:3.39E-02; Z-score:-1.61E+00

Methylation in Case

7.68E-02 (Median) Methylation in Control 1.28E-01 (Median)

Studied Phenotype

Prostate cancer[ ICD-11:2C82]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC24A3 in prostate cancer [ 8 ]

Location

TSS200 (cg21017569)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.27E+00 Statistic Test p-value:1.11E-03; Z-score:6.17E+00

Methylation in Case

8.46E-01 (Median) Methylation in Control 6.66E-01 (Median)

Studied Phenotype

Prostate cancer[ ICD-11:2C82]

Experimental Material

Patient tissue samples

  Pancretic ductal adenocarcinoma

           5 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC24A3 in pancretic ductal adenocarcinoma [ 9 ]

Location

Body (cg15992711)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.11E+00 Statistic Test p-value:2.21E-09; Z-score:-1.57E+00

Methylation in Case

3.92E-01 (Median) Methylation in Control 4.33E-01 (Median)

Studied Phenotype

Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC24A3 in pancretic ductal adenocarcinoma [ 9 ]

Location

Body (cg19347288)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.05E+00 Statistic Test p-value:8.31E-05; Z-score:-8.43E-01

Methylation in Case

7.41E-01 (Median) Methylation in Control 7.78E-01 (Median)

Studied Phenotype

Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC24A3 in pancretic ductal adenocarcinoma [ 9 ]

Location

Body (cg00588853)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-2.61E+00 Statistic Test p-value:9.02E-05; Z-score:-1.48E+00

Methylation in Case

1.18E-01 (Median) Methylation in Control 3.08E-01 (Median)

Studied Phenotype

Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon4

Methylation of SLC24A3 in pancretic ductal adenocarcinoma [ 9 ]

Location

Body (cg20651644)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.10E+00 Statistic Test p-value:1.93E-04; Z-score:-1.16E+00

Methylation in Case

7.60E-01 (Median) Methylation in Control 8.40E-01 (Median)

Studied Phenotype

Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon5

Methylation of SLC24A3 in pancretic ductal adenocarcinoma [ 9 ]

Location

Body (cg21399428)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.05E+00 Statistic Test p-value:3.46E-04; Z-score:8.75E-01

Methylation in Case

8.37E-01 (Median) Methylation in Control 7.96E-01 (Median)

Studied Phenotype

Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

Patient tissue samples

  Panic disorder

           3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC24A3 in panic disorder [ 10 ]

Location

Body (cg13805533)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.05E+00 Statistic Test p-value:6.15E-04; Z-score:4.50E-01

Methylation in Case

3.18E+00 (Median) Methylation in Control 3.04E+00 (Median)

Studied Phenotype

Panic disorder[ ICD-11:6B01]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC24A3 in panic disorder [ 10 ]

Location

Body (cg16172619)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.05E+00 Statistic Test p-value:1.62E-02; Z-score:4.12E-01

Methylation in Case

2.53E+00 (Median) Methylation in Control 2.41E+00 (Median)

Studied Phenotype

Panic disorder[ ICD-11:6B01]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC24A3 in panic disorder [ 10 ]

Location

Body (cg02718002)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.03E+00 Statistic Test p-value:3.71E-02; Z-score:4.17E-01

Methylation in Case

3.66E+00 (Median) Methylation in Control 3.56E+00 (Median)

Studied Phenotype

Panic disorder[ ICD-11:6B01]

Experimental Material

Patient tissue samples

  Papillary thyroid cancer

           6 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Methylation of SLC24A3 in papillary thyroid cancer [ 11 ]

Location

Body (cg00888479)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.31E+00 Statistic Test p-value:1.31E-05; Z-score:1.17E+00

Methylation in Case

8.12E-02 (Median) Methylation in Control 6.19E-02 (Median)

Studied Phenotype

Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon2

Methylation of SLC24A3 in papillary thyroid cancer [ 11 ]

Location

Body (cg13805533)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.02E+00 Statistic Test p-value:1.06E-04; Z-score:-7.33E-01

Methylation in Case

8.43E-01 (Median) Methylation in Control 8.63E-01 (Median)

Studied Phenotype

Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon3

Methylation of SLC24A3 in papillary thyroid cancer [ 11 ]

Location

Body (cg20194982)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.01E+00 Statistic Test p-value:7.55E-03; Z-score:-3.18E-01

Methylation in Case

9.42E-01 (Median) Methylation in Control 9.47E-01 (Median)

Studied Phenotype

Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon4

Methylation of SLC24A3 in papillary thyroid cancer [ 11 ]

Location

Body (cg16172619)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.00E+00 Statistic Test p-value:1.93E-02; Z-score:-1.85E-02

Methylation in Case

8.23E-01 (Median) Methylation in Control 8.24E-01 (Median)

Studied Phenotype

Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon5

Methylation of SLC24A3 in papillary thyroid cancer [ 11 ]

Location

Body (cg20244340)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:1.22E+00 Statistic Test p-value:4.46E-02; Z-score:8.06E-01

Methylation in Case

1.65E-01 (Median) Methylation in Control 1.35E-01 (Median)

Studied Phenotype

Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

Patient tissue samples

  Epigenetic Phenomenon6

Methylation of SLC24A3 in papillary thyroid cancer [ 11 ]

Location

3'UTR (cg19977363)

Epigenetic Type

Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

Fold Change:-1.01E+00 Statistic Test p-value:2.69E-03; Z-score:-7.40E-01

Methylation in Case

8.70E-01 (Median) Methylation in Control 8.80E-01 (Median)

Studied Phenotype

Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

Patient tissue samples

microRNA

  Unclear Phenotype

         10 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

let-7c directly targets SLC24A3 [ 12 ]

Epigenetic Type

microRNA Experiment Method PAR-CLIP

miRNA Stemloop ID

let-7c miRNA Mature ID let-7c-3p

miRNA Sequence

CUGUACAACCUUCUAGCUUUCC

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon2

miR-3177 directly targets SLC24A3 [ 12 ]

Epigenetic Type

microRNA Experiment Method PAR-CLIP

miRNA Stemloop ID

miR-3177 miRNA Mature ID miR-3177-5p

miRNA Sequence

UGUGUACACACGUGCCAGGCGCU

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon3

miR-4475 directly targets SLC24A3 [ 12 ]

Epigenetic Type

microRNA Experiment Method PAR-CLIP

miRNA Stemloop ID

miR-4475 miRNA Mature ID miR-4475

miRNA Sequence

CAAGGGACCAAGCAUUCAUUAU

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon4

miR-4668 directly targets SLC24A3 [ 12 ]

Epigenetic Type

microRNA Experiment Method PAR-CLIP

miRNA Stemloop ID

miR-4668 miRNA Mature ID miR-4668-5p

miRNA Sequence

AGGGAAAAAAAAAAGGAUUUGUC

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon5

miR-511 directly targets SLC24A3 [ 12 ]

Epigenetic Type

microRNA Experiment Method PAR-CLIP

miRNA Stemloop ID

miR-511 miRNA Mature ID miR-511-3p

miRNA Sequence

AAUGUGUAGCAAAAGACAGA

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon6

miR-548aa directly targets SLC24A3 [ 12 ]

Epigenetic Type

microRNA Experiment Method PAR-CLIP

miRNA Stemloop ID

miR-548aa miRNA Mature ID miR-548aa

miRNA Sequence

AAAAACCACAAUUACUUUUGCACCA

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon7

miR-548t directly targets SLC24A3 [ 12 ]

Epigenetic Type

microRNA Experiment Method PAR-CLIP

miRNA Stemloop ID

miR-548t miRNA Mature ID miR-548t-3p

miRNA Sequence

AAAAACCACAAUUACUUUUGCACCA

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon8

miR-5584 directly targets SLC24A3 [ 12 ]

Epigenetic Type

microRNA Experiment Method PAR-CLIP

miRNA Stemloop ID

miR-5584 miRNA Mature ID miR-5584-5p

miRNA Sequence

CAGGGAAAUGGGAAGAACUAGA

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon9

miR-624 directly targets SLC24A3 [ 12 ]

Epigenetic Type

microRNA Experiment Method PAR-CLIP

miRNA Stemloop ID

miR-624 miRNA Mature ID miR-624-3p

miRNA Sequence

CACAAGGUAUUGGUAUUACCU

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon10

miR-7845 directly targets SLC24A3 [ 12 ]

Epigenetic Type

microRNA Experiment Method PAR-CLIP

miRNA Stemloop ID

miR-7845 miRNA Mature ID miR-7845-5p

miRNA Sequence

AAGGGACAGGGAGGGUCGUGG

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human
References
1 Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips. Epigenetics. 2013 Sep;8(9):921-34.
2 DNA Methylation Dynamics in Urological Tumors.
3 Genome-wide Scan for Methylation Profiles in Breast Cancer
4 A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma. Nat Commun. 2015 Oct 30;6:8699.
5 Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8.
6 Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 Jan;8(1):34-43.
7 DNA methylation analysis of lung adenocarcinoma and adjacent non-tumor tissues
8 Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array. BMC Genomics. 2014 Jan 22;15:51.
9 Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer. 2014 Sep 1;135(5):1110-8.
10 DNA Methylation signatures in panic disorder. Transl Psychiatry. 2017 Dec 18;7(12):1287.
11 Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.
12 The Landscape of microRNA Targeting in Prostate Cancer Defined by AGO-PAR-CLIP. Neoplasia. 2016 Jun;18(6):356-70.

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