Detail Information of Epigenetic Regulations
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0098 Transporter Info | ||||
| Gene Name | SLC15A3 | ||||
| Transporter Name | Peptide/histidine transporter 2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Epigenetic Regulations of This DT (EGR) | |||||
|---|---|---|---|---|---|
|
Methylation |
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|
Head and neck squamous cell carcinoma |
1 Epigenetic Phenomena Related to This Phenotype | Click to Show/Hide the Full List | |||
|
Epigenetic Phenomenon1 |
Hypermethylation of SLC15A3 in HNSCC | [ 1 ] | |||
|
Location |
Promoter (CpG island) | ||||
|
Epigenetic Type |
Methylation | Experiment Method | Subtractive hybridization & microarray | ||
|
Related Molecular Changes | Up regulation ofSLC15A3 | Experiment Method | Bisulfite sequencing, qRT-PCR | ||
|
Studied Phenotype |
Head and neck squamous cell carcinoma[ ICD-11:2B6E] | ||||
|
Experimental Material |
HNSCC cell lines (FaDu, UM-SCC-14A, UM-SCC-17A, UM-SCC-38A) | ||||
|
Additional Notes |
SLC15A3 is epigenetically silenced by promoter hypermethylation in HNSCC. Reactivated by 5-aza-2'-deoxycytidine (5Aza-dC) treatment with >3-fold expression increase. Identified through combined subtractive hybridization and microarray analysis. | ||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Epigenetic silencing of CRABP2 and MX1 in head and neck tumors. Neoplasia. 2009 Dec;11(12):1329-39. | ||||
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