Detail Information of Epigenetic Regulations

General Information of Drug Transporter (DT)
DT ID DTD0019 Transporter Info
Gene Name SLC10A1
Transporter Name Sodium/taurocholate cotransporting polypeptide
Gene ID
6554
UniProt ID
Q14973
Epigenetic Regulations of This DT (EGR)

Methylation

  Pancretic ductal adenocarcinoma

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC10A1 in pancretic ductal adenocarcinoma [ 1 ]

Location

 5'UTR (cg23956760)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.06E+00 Statistic Test p-value:9.50E-04; Z-score:-8.11E-01

Methylation in Case

 7.46E-01 (Median) Methylation in Control 7.89E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC10A1 in pancretic ductal adenocarcinoma [ 1 ]

Location

 Body (cg14528437)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.01E+00 Statistic Test p-value:3.68E-03; Z-score:4.70E-01

Methylation in Case

 9.32E-01 (Median) Methylation in Control 9.21E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Bladder cancer

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC10A1 in bladder cancer [ 2 ]

Location

 TSS1500 (cg21088438)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.81E+00 Statistic Test p-value:2.18E-08; Z-score:-7.12E+00

Methylation in Case

 3.37E-01 (Median) Methylation in Control 6.12E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC10A1 in bladder cancer [ 2 ]

Location

 TSS1500 (cg24053811)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.03E+00 Statistic Test p-value:1.98E-03; Z-score:-1.62E+00

Methylation in Case

 7.88E-01 (Median) Methylation in Control 8.11E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC10A1 in bladder cancer [ 2 ]

Location

 3'UTR (cg14059534)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.06E+00 Statistic Test p-value:5.74E-04; Z-score:-5.25E+00

Methylation in Case

 8.09E-01 (Median) Methylation in Control 8.57E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Colorectal cancer

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC10A1 in colorectal cancer [ 3 ]

Location

 TSS1500 (cg24053811)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.00E+00 Statistic Test p-value:3.57E-02; Z-score:-2.27E-01

Methylation in Case

 9.38E-01 (Median) Methylation in Control 9.40E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC10A1 in colorectal cancer [ 3 ]

Location

 1stExon (cg05633152)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.00E+00 Statistic Test p-value:4.28E-02; Z-score:-2.57E-01

Methylation in Case

 9.36E-01 (Median) Methylation in Control 9.39E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  HIV infection

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC10A1 in HIV infection [ 4 ]

Location

 TSS1500 (cg21088438)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.51E+00 Statistic Test p-value:7.47E-09; Z-score:2.61E+00

Methylation in Case

 6.11E-01 (Median) Methylation in Control 4.04E-01 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC10A1 in HIV infection [ 4 ]

Location

 TSS200 (cg01448863)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.70E+00 Statistic Test p-value:1.76E-08; Z-score:3.43E+00

Methylation in Case

 6.26E-01 (Median) Methylation in Control 3.68E-01 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC10A1 in HIV infection [ 4 ]

Location

 3'UTR (cg14059534)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.01E+00 Statistic Test p-value:3.28E-02; Z-score:1.09E-01

Methylation in Case

 9.15E-01 (Median) Methylation in Control 9.09E-01 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Panic disorder

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC10A1 in panic disorder [ 5 ]

Location

 TSS1500 (cg03234661)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.05E+00 Statistic Test p-value:1.06E-03; Z-score:7.19E-01

Methylation in Case

 3.29E+00 (Median) Methylation in Control 3.13E+00 (Median)

Studied Phenotype

 Panic disorder[ ICD-11:6B01]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC10A1 in panic disorder [ 5 ]

Location

 TSS1500 (cg21088438)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-7.37E-01 Statistic Test p-value:4.46E-02; Z-score:-4.83E-01

Methylation in Case

 -1.21E+00 (Median) Methylation in Control -8.93E-01 (Median)

Studied Phenotype

 Panic disorder[ ICD-11:6B01]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC10A1 in panic disorder [ 5 ]

Location

 TSS200 (cg01448863)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-6.96E-01 Statistic Test p-value:5.41E-04; Z-score:-6.21E-01

Methylation in Case

 -1.48E+00 (Median) Methylation in Control -1.03E+00 (Median)

Studied Phenotype

 Panic disorder[ ICD-11:6B01]

Experimental Material

 Patient tissue samples

  Papillary thyroid cancer

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC10A1 in papillary thyroid cancer [ 6 ]

Location

 TSS1500 (cg03054387)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.01E+00 Statistic Test p-value:3.10E-02; Z-score:4.73E-01

Methylation in Case

 9.29E-01 (Median) Methylation in Control 9.21E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC10A1 in papillary thyroid cancer [ 6 ]

Location

 TSS200 (cg01448863)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.04E+00 Statistic Test p-value:4.11E-04; Z-score:-7.18E-01

Methylation in Case

 8.27E-01 (Median) Methylation in Control 8.59E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC10A1 in papillary thyroid cancer [ 6 ]

Location

 1stExon (cg05633152)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.01E+00 Statistic Test p-value:4.99E-03; Z-score:-7.66E-01

Methylation in Case

 9.12E-01 (Median) Methylation in Control 9.24E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Breast cancer

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC10A1 in breast cancer [ 7 ]

Location

 TSS200 (cg01448863)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.06E+00 Statistic Test p-value:5.32E-03; Z-score:-4.70E-01

Methylation in Case

 6.01E-01 (Median) Methylation in Control 6.35E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC10A1 in breast cancer [ 7 ]

Location

 1stExon (cg05633152)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.01E+00 Statistic Test p-value:1.45E-02; Z-score:-3.06E-01

Methylation in Case

 8.19E-01 (Median) Methylation in Control 8.28E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Hepatocellular carcinoma

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC10A1 in hepatocellular carcinoma [ 8 ]

Location

 TSS200 (cg01448863)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.39E+00 Statistic Test p-value:9.62E-04; Z-score:-1.02E+00

Methylation in Case

 2.47E-01 (Median) Methylation in Control 3.43E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC10A1 in hepatocellular carcinoma [ 8 ]

Location

 1stExon (cg05633152)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.16E+00 Statistic Test p-value:2.72E-02; Z-score:-6.21E-01

Methylation in Case

 4.74E-01 (Median) Methylation in Control 5.50E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC10A1 in hepatocellular carcinoma [ 8 ]

Location

 Body (cg20482113)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.25E+00 Statistic Test p-value:1.77E-05; Z-score:-1.13E+00

Methylation in Case

 5.17E-01 (Median) Methylation in Control 6.48E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Atypical teratoid rhabdoid tumor

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC10A1 in atypical teratoid rhabdoid tumor [ 9 ]

Location

 1stExon (cg05633152)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.37E+00 Statistic Test p-value:9.51E-24; Z-score:-3.94E+00

Methylation in Case

 6.38E-01 (Median) Methylation in Control 8.74E-01 (Median)

Studied Phenotype

 Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC10A1 in atypical teratoid rhabdoid tumor [ 9 ]

Location

 3'UTR (cg14059534)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.24E+00 Statistic Test p-value:2.77E-11; Z-score:-1.87E+00

Methylation in Case

 6.22E-01 (Median) Methylation in Control 7.72E-01 (Median)

Studied Phenotype

 Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]

Experimental Material

 Patient tissue samples

  Ovarian cancer

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Moderate hypermethylation of SLC10A1 in ovarian cancer than that in healthy individual

Studied Phenotype

 Ovarian cancer [ICD-11:2C73]

The Methylation Level of Disease Section Compare with the Healthy Individual

 p-value:0.004890043; Fold-change:0.214457143; Z-score:1.576519775
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue
Download DT methylation data in the tissue of healthy individual

  Uterine carcinosarcoma

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Moderate hypermethylation of SLC10A1 in uterine carcinosarcoma than that in healthy individual

Studied Phenotype

 Uterine carcinosarcoma [ICD-11:2B5F]

The Methylation Level of Disease Section Compare with the Healthy Individual

 p-value:9.72E-05; Fold-change:0.275485908; Z-score:2.022884579
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue
Download DT methylation data in the tissue of healthy individual

  Liver cancer

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Moderate hypomethylation of SLC10A1 in liver cancer than that in healthy individual

Studied Phenotype

 Liver cancer [ICD-11:2C12]

The Methylation Level of Disease Section Compare with the Healthy Individual

 p-value:5.67E-08; Fold-change:-0.222428787; Z-score:-1.765477765
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue adjacent to the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
DT methylation level in tissue other than the diseased tissue of patients
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue
Download DT methylation data of patients in the normal section of the tissue adjacent to the disease section
Download DT methylation data in the tissue of healthy individual
Download DT methylation data in the tissue of the other disease section

  Meningioma

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Moderate hypomethylation of SLC10A1 in meningioma than that in healthy individual

Studied Phenotype

 Meningioma [ICD-11:2A01.0Z]

The Methylation Level of Disease Section Compare with the Healthy Individual

 p-value:1.01E-24; Fold-change:-0.228155535; Z-score:-1.975918421
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue
Download DT methylation data in the tissue of healthy individual

  Prostate cancer

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Significant hypermethylation of SLC10A1 in prostate cancer than that in healthy individual

Studied Phenotype

 Prostate cancer [ICD-11:2C82]

The Methylation Level of Disease Section Compare with the Healthy Individual

 p-value:0.001052422; Fold-change:0.688400059; Z-score:2.010077245
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue
Download DT methylation data in the tissue of healthy individual

  Central neurocytoma

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Significant hypomethylation of SLC10A1 in central neurocytoma than that in healthy individual

Studied Phenotype

 Central neurocytoma [ICD-11:2A00.3]

The Methylation Level of Disease Section Compare with the Healthy Individual

 p-value:2.45E-11; Fold-change:-0.514748594; Z-score:-5.262430477
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue
Download DT methylation data in the tissue of healthy individual

  Cerebellar liponeurocytoma

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Significant hypomethylation of SLC10A1 in cerebellar liponeurocytoma than that in healthy individual

Studied Phenotype

 Cerebellar liponeurocytoma [ICD-11:2A00.0Y]

The Methylation Level of Disease Section Compare with the Healthy Individual

 p-value:0.025587334; Fold-change:-0.424536935; Z-score:-1.554050893
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue
Download DT methylation data in the tissue of healthy individual

  Obesity

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Significant hypomethylation of SLC10A1 in obesity than that in healthy individual

Studied Phenotype

 Obesity [ICD-11:5B81]

The Methylation Level of Disease Section Compare with the Healthy Individual

 p-value:6.33E-13; Fold-change:-0.50087805; Z-score:-3.042758424
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue
Download DT methylation data in the tissue of healthy individual

  Gastric cancer

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Significant hypermethylation of SLC10A1 in gastric cancer than that in adjacent tissue

Studied Phenotype

 Gastric cancer [ICD-11:2B72]

The Methylation Level of Disease Section Compare with the Adjacent Tissue

 p-value:0.048180188; Fold-change:0.421457503; Z-score:2.711564329
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue adjacent to the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Download DT methylation data of patients in the disease section of the tissue
Download DT methylation data of patients in the normal section of the tissue adjacent to the disease section
Download DT methylation data in the tissue of healthy individual

Histone acetylation

  Hepatocellular carcinoma

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Loss of H3K27ac in SLC10A1 in Hepatocellular carcinoma [ 10 ]

Location

 Promoter

Epigenetic Type

 Histone acetylation Experiment Method .

Related Molecular Changes

 Down regulation ofSLC10A1 Experiment Method RT-qPCR

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12]

Experimental Material

 HepG2 cells, primary human hepatocytes, HCC tissues

Additional Notes

 hNTCP expression is downregulated in HCC due to loss of activating histone mark H3K27ac at the transcription start site. HDAC inhibitor treatment restores H3K27ac levels and GR binding, reactivating hNTCP expression and making cells susceptible to HBV infection.
References
1 Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer. 2014 Sep 1;135(5):1110-8.
2 DNA Methylation Dynamics in Urological Tumors.
3 Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8.
4 HIV-1 Infection Accelerates Age According to the Epigenetic Clock. J Infect Dis. 2015 Nov 15;212(10):1563-73.
5 DNA Methylation signatures in panic disorder. Transl Psychiatry. 2017 Dec 18;7(12):1287.
6 Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.
7 Genome-wide Scan for Methylation Profiles in Breast Cancer
8 Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 Jan;8(1):34-43.
9 Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. Cancer Cell. 2016 Mar 14;29(3):379-393.
10 The loss of hepatitis B virus receptor NTCP/SLC10A1 in human liver cancer cells is due to epigenetic silencing. J Virol. 2024 Oct 22;98(10):e0118724.

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