Drug Information

General Information
Drug ID
DR01431
Drug Name
Famciclovir
Synonyms
FCV; Famciclovirum; Famvir; Oravir; BRL 42810; IN1338; Anti-Farnesyl Rabbit pAb; BRL-42810; Famciclovirum [INN-Latin]; Famvir (TN); Famciclovir [USAN:BAN:INN]; Famciclovir (JAN/USAN/INN); [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate; Diacetyl 6-deoxy-9-(4-hydroxy-3-hydroxymethyl-but-1-yl)guanine; 1,3-Propanediol, 2-(2-(2-amino-9H-purin-9-yl)ethyl)-, diacetate (ester); 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate (ester); 2-(2-(2-amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate; 2-(acetoxymethyl)-4-(2-amino-4,5-dihydro-9H-purin-9-yl)butyl acetate; 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate; 2-[2-(2-amino-9H-purin-9-yl)ethyl]-1,3-propanediol diacetate; 9-(4-acetoxy-3-(acetoxymethyl)but-1-yl)-2-aminopurine; 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine
Drug Type
Small molecular drug
Indication Viral infections [ICD11:1D90-1D9Z] Approved [1]
Therapeutic Class
Antiviral Agents
Structure
3D MOL 2D MOL
Formula
C14H19N5O4
Canonical SMILES
CC(=O)OCC(CCN1C=NC2=CN=C(N=C21)N)COC(=O)C
InChI
InChI=1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
InChIKey
GGXKWVWZWMLJEH-UHFFFAOYSA-N
CAS Number
CAS 104227-87-4
Pharmaceutical Properties Molecular Weight 321.33 Topological Polar Surface Area 122
Heavy Atom Count 23 Rotatable Bond Count 9
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 8
XLogP
0
PubChem CID
3324
PubChem SID
626303 ,5276651 ,7847383 ,7979216 ,8152111 ,11363360 ,11365922 ,11368484 ,11372808 ,11374301 ,11376646 ,11484938 ,11488917 ,11491490 ,11492426 ,11494280 ,11528705 ,12013946 ,14899331 ,26612822 ,26680213 ,26719883 ,26748972 ,26748973 ,26758694 ,29222459 ,46386745 ,46507561 ,47291220 ,47515410 ,48415997 ,49681753 ,50107498 ,52712677 ,53800778 ,56313627 ,57321725 ,68530529 ,81092805 ,85173809 ,85787983 ,92124793 ,92308042 ,92308372 ,92309126 ,92710468 ,103158204 ,103231964 ,104253634 ,104303176
ChEBI ID
CHEBI:4974
TTD Drug ID
D0VT8P
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
References
1 Famciclovir was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37.

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