Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01428
|
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| Drug Name |
Pirenzepine
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| Synonyms |
Gasteril; Gastrotsepin; Gastrozepin; Pirenzepin; Pirenzepina; Pirenzepinum; Pyrenzepine; Ulcosan; Pirenzepine Gastrozepin; Gastrozepin (TN); L-S 519; Pirenzepina [INN-Spanish]; Pirenzepine (INN); Pirenzepine [INN:BAN]; Pirenzepinum [INN-Latin]; 11-((4-Methyl-1-piperazinyl)acetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one; 11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one; 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one; 5,11-Dihydro-11-((4-methyl-1-piperazinyl)acetyl)-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one
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| Drug Type |
Small molecular drug
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| Indication | Peptic ulcer [ICD11:DA61] | Approved | [1] | |||
| Therapeutic Class |
Antiulcer Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C19H21N5O2
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| Canonical SMILES |
CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
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| InChI |
InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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| InChIKey |
RMHMFHUVIITRHF-UHFFFAOYSA-N
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| CAS Number |
CAS 28797-61-7
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| Pharmaceutical Properties | Molecular Weight | 351.4 | Topological Polar Surface Area | 68.8 | ||
| Heavy Atom Count | 26 | Rotatable Bond Count | 2 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 5 | |||
| XLogP |
0.1
|
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| PubChem CID | ||||||
| PubChem SID |
9711
,5518525
,7980332
,8152981
,11111661
,11111662
,11113363
,11335302
,11360541
,11364272
,11366834
,11369396
,11372544
,11373933
,11377558
,11461513
,11466157
,11467277
,11485230
,11485853
,11489233
,11491268
,11492252
,11495192
,14852009
,26751604
,29223929
,46509029
,47211770
,47216642
,47365035
,47365036
,47515172
,47588849
,47959578
,47959579
,48110309
,48334341
,48416446
,49698919
,50034085
,50100327
,50104261
,50139450
,50423922
,57322487
,81065495
,81093320
,85209239
,85787888
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| ChEBI ID |
ChEBI:8247
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | National Center for Advancing Translational Science-Inxight: drug (3G0285N20N) | |||||
| 2 | Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. | |||||
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