Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01418
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| Drug Name |
Acrivastine
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| Synonyms |
Acrivastin; Acrivastina; Acrivastinum; Semprex; Acrivastina [Spanish]; Acrivastinum [Latin]; Benadryl allergy relief; BW 0270C; BW 825C; BW A825C; BW-825C; Acrivastine (USAN/INN); Acrivastine [USAN:INN:BAN]; E-(9CI); (2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-en-1-yl]pyridin-2-yl}prop-2-enoic acid; (E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-yl]prop-2-enoic acid; (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid; (E)-6-((E)-3-(1-Pyrrolidinyl-1-p-tolylpropenyl)-2-pyridinacrylsaeure; (E,E)-3-[6-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-2-pyridinyl]-2-propenoic acid; 3-{6-[1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}prop-2-enoic acid
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| Drug Type |
Small molecular drug
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| Indication | Seasonal allergic rhinitis [ICD11:CA08.01] | Approved | [1] | |||
| Therapeutic Class |
Antiinflammatory Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C22H24N2O2
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| Canonical SMILES |
CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC(=N3)C=CC(=O)O
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| InChI |
InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+
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| InChIKey |
PWACSDKDOHSSQD-IUTFFREVSA-N
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| CAS Number |
CAS 87848-99-5
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| Pharmaceutical Properties | Molecular Weight | 348.4 | Topological Polar Surface Area | 53.4 | ||
| Heavy Atom Count | 26 | Rotatable Bond Count | 6 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 4 | |||
| XLogP |
1.6
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| PubChem CID | ||||||
| PubChem SID |
7978641
,11039320
,11528790
,12012900
,14827611
,17396918
,39317835
,48415515
,50478506
,57359099
,92719198
,92729786
,93166367
,93309492
,99299401
,103374556
,104178336
,109614385
,113863077
,117544906
,124893773
,126628312
,126651909
,126670557
,127327803
,134338557
,135260703
,137100857
,142971128
,144206566
,162180352
,175268536
,179151367
,185967402
,196106033
,223447811
,223683999
,223704756
,226396645
,252344698
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| ChEBI ID |
CHEBI:83168
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Acrivastine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. | |||||
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