Drug Information

General Information
Drug ID
DR01416
Drug Name
Enalaprilat
Synonyms
EAL; Enalaprilate; Enalaprilatum; ENALAPRILAT INHIBITOR; Enalapril acid; Enalapril diacid; Enalaprilat anhydrous; Enalaprilic acid; Enalprilat hydrate; Enalprilate hydrate; Enalaprilat (USP); MK-422; Vasotec I.V.; N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline; N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline-water (1/2); (2S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid; (2S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid dihydrate; 1-((2S)-2-{[(1S)-1-CARBOXY-3-PHENYLPROPYL]AMINO}PROPANOYL)-L-PROLINE; 1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline dihydrate
Drug Type
Small molecular drug
Indication High blood pressure [ICD11:BA00] Approved [1]
Therapeutic Class
Antihypertensive Agents
Structure
3D MOL 2D MOL
Formula
C18H24N2O5
Canonical SMILES
CC(C(=O)N1CCCC1C(=O)O)NC(CCC2=CC=CC=C2)C(=O)O
InChI
InChI=1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1
InChIKey
LZFZMUMEGBBDTC-QEJZJMRPSA-N
CAS Number
CAS 76420-72-9
Pharmaceutical Properties Molecular Weight 348.4 Topological Polar Surface Area 107
Heavy Atom Count 25 Rotatable Bond Count 8
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 6
XLogP
-0.7
PubChem CID
5462501
PubChem SID
13885 ,7887268 ,11688562 ,14876097 ,14900718 ,26719866 ,26758015 ,39459536 ,46386741 ,49681611 ,50070755 ,50466382 ,92308386 ,92308980 ,93166910 ,93311012 ,93577953 ,99313641 ,103179234 ,104253291 ,114004069 ,118313442 ,121362057 ,124659029 ,124757412 ,124800027 ,125164216 ,126650398 ,128562671 ,131325846 ,134221872 ,135012534 ,137024395 ,143297080 ,144076246 ,151979549 ,152031989 ,160661062 ,160846356 ,162176890 ,162262134 ,163564990 ,164786777 ,165698333 ,172080415 ,172913628 ,175266379 ,176484234 ,176484707 ,178102950
ChEBI ID
CHEBI:4786
TTD Drug ID
D0N5HJ
DT(s) Transporting This Drug PEPT1 Transporter Info Peptide transporter 1 Substrate [2]
References
1 Enalaprilat was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74.

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