Drug Information

General Information
Drug ID
DR01410
Drug Name
Guanabenz
Synonyms
GBZ; Guanabenzo; Guanabenzum; Wytensin; Guanabenz acetate; Guanabenz monoacetate; Wy 8678; Wy 8678 base; BR-750; Guanabenz [USAN:INN]; Guanabenz(USAN); Guanabenzo [INN-Spanish]; Guanabenzum [INN-Latin]; Wy-8678; Wytensin (TN); Guanabenz (USAN/INN); [(2,6-Dichlorobenzylidene)amino]guanidine; N-((2,6-Dichlorobenzylidene)amino)guanidine; Guanidine, ((2,6-dichlorobenzylidene)amino)-(8CI); N-(2,6-Dichlorobenzylidene)-N'-amidinohydrazine; ((2,6-Dichlorobenzylidene)amino)guanidine; 2,6-Dichlorobenzylideneaminoguanidine;2-((2,6-Dichlorophenyl)methylene)-hydrazinecarboximidamide; 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine
Drug Type
Small molecular drug
Indication Hypertension [ICD11:BA00] Approved [1]
Therapeutic Class
Sympatholytics
Structure
3D MOL 2D MOL
Formula
C8H8Cl2N4
Canonical SMILES
C1=CC(=C(C(=C1)Cl)C=NN=C(N)N)Cl
InChI
InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+
InChIKey
WDZVGELJXXEGPV-YIXHJXPBSA-N
CAS Number
CAS 5051-62-7
Pharmaceutical Properties Molecular Weight 231.08 Topological Polar Surface Area 76.8
Heavy Atom Count 14 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
XLogP
1.7
PubChem CID
5702063
PubChem SID
9246 ,113005 ,15390940 ,17434456 ,24607029 ,26665151 ,26751943 ,47206274 ,47795034 ,48018892 ,48169358 ,48243349 ,48318400 ,49698340 ,50064822 ,50070697 ,50104618 ,50104619 ,57364886 ,78424678 ,81642163 ,85209545 ,85787575 ,88878415 ,90341577 ,92098556 ,92308809 ,103164806 ,103826246 ,103936653 ,114069183 ,117464955 ,124749846 ,124886953 ,126876159 ,131342553 ,131342557 ,134337546 ,134984370 ,137010571 ,137144691 ,137149965 ,139524299 ,145257345 ,160963974 ,164037969 ,164819317 ,175266630 ,176483965 ,179038222
ChEBI ID
CHEBI:5553
TTD Drug ID
D0L4HY
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
References
1 Guanabenz was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26.

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