Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01392
|
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| Drug Name |
Betamethasone
|
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| Synonyms |
betamethasone; 378-44-9; Betadexamethasone; Flubenisolone; Betamethazone; Rinderon; Visubeta; Celestene; Betnelan; Betapredol; Betacortril; Betacorlan; Methazon; Betsolan; Betamamallet; Hormezon; Betasolon; Betametasone; Cidoten; Bebate; Bedifos; Becort; beta-Methasone; Desacort-Beta; Rinderon A; beta-Methasone alcohol; Betametasona; Betafluorene; Betamethasonum; Celestone; Betamethasone cream; Betamethasone alcohol; Betametasone [DCIT]; 9alpha-Fluoro-16beta-methylprednisolone; Celestone Syrup and Tablets; Celeston; Celestona; Cellestoderm; Luxiqo; Betamethasone Base; Betamethasone Valearate; Betamethasonvalerat Mikron; LT00441022; SCH 4831; Beta-Methasone; Beta-Methasone alcohol; Betametasona [INN-Spanish]; Betamethasonum [INN-Latin]; Betnovate (TN); Celestone (TN); Diprolene (TN); Diprosone (TN); Lotrisone (TN); Rinderon (TN); SCH-4831; Betamethasone (JP15/USP/INN); Betamethasone [USAN:BAN:INN:JAN]; Betamethasone [USAN:INN:BAN:JAN]; Celestone, Betadexamethasone, Flubenisolone, Sch-4831, NCS-39470, Betamethasone; 1,4-Pregnadiene-3,20-dione-9alpha-fluoro-16 beta-methyl-11 beta,17alpha,21-triol; 16beta-Methyl-1,4-pregnadiene-9alpha-fluoro-11beta,17alpha,21-triol-3,20-dione; 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-16beta-methylprednisolone; 9-alpha-Fluoro-16-beta-methylprednisolone; 9alpha-Fluoro-16 beta-methyl-prednisolone; Betamethasone sodium phosphate
|
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| Drug Type |
Small molecular drug
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| Indication | Asthma [ICD11:CA23] | Approved | [1] | |||
| Therapeutic Class |
Antiinflammatory Agents
|
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| Structure |
|
 |
||||
| 3D MOL | 2D MOL | |||||
| Formula |
C22H29FO5
|
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| Canonical SMILES |
CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
|
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| InChI |
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
|
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| InChIKey |
UREBDLICKHMUKA-DVTGEIKXSA-N
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| CAS Number |
CAS 378-44-9
|
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| Pharmaceutical Properties | Molecular Weight | 392.5 | Topological Polar Surface Area | 94.8 | ||
| Heavy Atom Count | 28 | Rotatable Bond Count | 2 | |||
| Hydrogen Bond Donor Count | 3 | Hydrogen Bond Acceptor Count | 6 | |||
| XLogP |
1.9
|
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| PubChem CID | ||||||
| PubChem SID |
9066
,625879
,3161499
,7847310
,7978781
,8157046
,10321659
,11466390
,11467510
,11486140
,12159278
,14756597
,15004923
,24278276
,24860978
,24892150
,26757820
,29228348
,46500420
,46505155
,46530919
,47193705
,47499670
,47720710
,47720711
,47943900
,48019043
,48415627
,49698457
,50019449
,50111677
,53789445
,56320847
,56462985
,57288752
,57649117
,57653954
,75637045
,85788058
,87564725
,87568418
,92125449
,93167065
,103188847
,103914147
,104253177
,104321493
,121363120
,124757297
,124800522
|
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| ChEBI ID |
ChEBI:3077
|
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Betamethasone was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. | |||||
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