Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01379
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| Drug Name |
Mequitazine
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| Synonyms |
Butix; Instotal; Kitazemin; Mequitazina; Mequitazinum; Metaplexan; Mircol; Primalan; Quitadrill; Vigigan; Virginan; Zesulan; Italfarmaco brand of mequitazine; Mequitazina [Spanish]; Mequitazine hydrochloride; Pierre Fabre brand of mequitazine; LM 209; Kitazemin (TN); LM-209; Mequitazina [INN-Spanish]; Mequitazinum [INN-Latin]; Mequitazine (JP15/INN); Mequitazine [INN:BAN:DCF:JAN]; Mequitazine tartrate, (R-(R*,R*))-isomer; 10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine; 10-(1-azabicyclo(2.2.2)oct-8-ylmethyl)phenothiazine; 10-(1-azabicyclo[2.2.2]octan-3-ylmethyl)phenothiazine; 10-(3-Quinuclidinylmethyl)phenothiazine; 10H-Phenothiazine, 10-(1-azabicyclo(2.2.2)oct-3-ylmethyl)-(9CI); 3-Methylquinuclidinyl-10-phenothiazine
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| Drug Type |
Small molecular drug
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| Indication | Allergic rhinitis [ICD11:CA08.0] | Approved | [1] | |||
| Therapeutic Class |
Antihistamines
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C20H22N2S
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| Canonical SMILES |
C1CN2CCC1C(C2)CN3C4=CC=CC=C4SC5=CC=CC=C53
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| InChI |
InChI=1S/C20H22N2S/c1-3-7-19-17(5-1)22(18-6-2-4-8-20(18)23-19)14-16-13-21-11-9-15(16)10-12-21/h1-8,15-16H,9-14H2
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| InChIKey |
HOKDBMAJZXIPGC-UHFFFAOYSA-N
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| CAS Number |
CAS 29216-28-2
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| Pharmaceutical Properties | Molecular Weight | 322.5 | Topological Polar Surface Area | 31.8 | ||
| Heavy Atom Count | 23 | Rotatable Bond Count | 2 | |||
| Hydrogen Bond Donor Count | 0 | Hydrogen Bond Acceptor Count | 3 | |||
| XLogP |
4.6
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| PubChem CID | ||||||
| PubChem SID |
453325
,583144
,7366094
,7848387
,8141047
,8152552
,10320045
,10517343
,11406959
,14850608
,16617285
,26665232
,29223177
,46505779
,48416221
,50006661
,53787706
,56320321
,57322124
,57962172
,78247115
,81093314
,85209426
,87244027
,92714662
,103267575
,103815311
,104305332
,104972177
,117404379
,124799813
,124894252
,125347181
,126623962
,126655271
,126669303
,128089981
,131309176
,134338335
,134997033
,137267684
,140724147
,142143428
,144207197
,160964405
,163121882
,164761785
,164814342
,170005238
,170465794
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| ChEBI ID |
CHEBI:31821
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | National Center for Advancing Translational Science-Inxight: drug (Y463242LY2) | |||||
| 2 | Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. | |||||
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