Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01367
|
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| Drug Name |
Cycloheximide
|
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| Synonyms |
naramycin A; NSC 185; FT 3422-2; NM-MCD 80
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| Drug Type |
Small molecular drug
|
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| Indication | Fungal infections [ICD11:1F20-1F2Z] | Preclinical | [1] | |||
| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C15H23NO4
|
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| Canonical SMILES |
CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C
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| InChI |
InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
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| InChIKey |
YPHMISFOHDHNIV-FSZOTQKASA-N
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| CAS Number |
CAS 66-81-9
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| Pharmaceutical Properties | Molecular Weight | 281.35 | Topological Polar Surface Area | 83.5 | ||
| Heavy Atom Count | 20 | Rotatable Bond Count | 3 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 4 | |||
| XLogP |
0.5
|
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| PubChem CID | ||||||
| PubChem SID |
8910
,67121
,590053
,600085
,842009
,3132584
,8137762
,8149831
,8153887
,10321885
,11335225
,11360464
,11364238
,11366800
,11369362
,11372758
,11374546
,11377524
,11405933
,11461436
,11466818
,11467938
,11484456
,11486575
,11488716
,11491325
,11492729
,11495158
,12159014
,16602052
,17389082
,17389083
,17397729
,24262965
,24844217
,24845200
,24845201
,24850897
,24870128
,24892457
,24892732
,24892981
,26612307
,26679972
,26752000
,26758517
,29225195
,46391373
,47423774
,47499094
|
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| ChEBI ID |
CHEBI:27641
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Fungicides, Agricultural, 2. Individual Fungicides | |||||
| 2 | Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87. | |||||
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