Drug Information

General Information
Drug ID
DR01349
Drug Name
Karenitecin
Synonyms
Karenitecin (TN)
Drug Type
Small molecular drug
Indication Ovarian cancer [ICD11:2C73] Phase 3 [1]
Structure
3D MOL 2D MOL
Formula
C25H28N2O4Si
Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CC[Si](C)(C)C)O
InChI
InChI=1S/C25H28N2O4Si/c1-5-25(30)19-12-21-22-17(13-27(21)23(28)18(19)14-31-24(25)29)15(10-11-32(2,3)4)16-8-6-7-9-20(16)26-22/h6-9,12,30H,5,10-11,13-14H2,1-4H3/t25-/m0/s1
InChIKey
POADTFBBIXOWFJ-VWLOTQADSA-N
CAS Number
CAS 203923-89-1
Pharmaceutical Properties Molecular Weight 448.6 Topological Polar Surface Area 79.7
Heavy Atom Count 32 Rotatable Bond Count 4
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5
PubChem CID
148202
PubChem SID
530668 ,10249845 ,11443149 ,14906395 ,46225149 ,50873155 ,57346730 ,96026007 ,104418481 ,126681210 ,135105770 ,140587255 ,172918703 ,175427037 ,184826536 ,198949673 ,223663599 ,228436255 ,241051100 ,242534801 ,246301288 ,252215634
TTD Drug ID
D02CZK
DT(s) Transporting This Drug BCRP Transporter Info Breast cancer resistance protein Substrate [2]
OATP1B1 Transporter Info Organic anion transporting polypeptide 1B1 Substrate [3]
References
1 ClinicalTrials.gov (NCT00477282) Karenitecin Versus Topotecan in Patients With Advanced Epithelial Ovarian Cancer
2 Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9.
3 Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81.

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