Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01341
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| Drug Name |
Triamterene
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| Synonyms |
Ademin; Ademine; Amteren; Anjal; Dazid; Diarol; Dinazide; Diren; Ditak; Diucelpin; Diurene; Diutensat; Diuteren; Dyberzide; Dyren; Dyrenium; Dytac; Dytenzide; Esiteren; Hidiurese; Hydrene; Hypertorr; Isobar; Jatropur; Jenateren; Kalspare; Masuharmin; Nephral; Noridil; Noridyl; Pterofen; Pterophene; Renezide; Reviten; Taturil; Teriam; Teridin; Triamizide; Triampur; Triamteren; Triamterena; Triamterenum; Triamteril; Triamterine; Triamthiazid; Tricilone; Trispan; Triteren; Triurene; Trizid; Turfa; Uretren; Urocaudal; Goldshield Brand of Triamterene; Jorba Brand of Triamterene; Pter ophene; SmithKline Beecham Brand of Triamterene; TRIAMTERENE USP; Thiazid Wolff; Triamteril complex; Wellspring Brand of Triamterene; Fluss 40; SKF 8542; T 4143; Ademin(e); Apo-triazide; Dyrenium (TN); Pteridine deriv. 11; SALI-PUREN; SK&F 8542; SK-8542; Tri-Span; Triamterena [INN-Spanish]; Triamterenum [INN-Latin]; SK&F-8542; Triamterene (JP15/USP/INN); Triamterene [USAN:INN:BAN:JAN]; 2,4,7-Triamino-6-fenilpteridina; 2,4,7-Triamino-6-fenilpteridina [Italian]; 2,4,7-Triamino-6-phenylpteridine; 6-PHENYL-2,4,7-TRIAMINO PTERIDINE; 6-Phenyl-2,4,7-pteridinetriamine; 6-Phenyl-2,4,7-triaminopteridine; 6-phenylpteridine-2,4,7-triamine
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| Drug Type |
Small molecular drug
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| Indication | Edema associated with congestive heart failure [ICD11:BD10] | Approved | [1] | |||
| Therapeutic Class |
Diuretics
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C12H11N7
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| Canonical SMILES |
C1=CC=C(C=C1)C2=NC3=C(N=C(N=C3N=C2N)N)N
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| InChI |
InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
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| InChIKey |
FNYLWPVRPXGIIP-UHFFFAOYSA-N
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| CAS Number |
CAS 396-01-0
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| Pharmaceutical Properties | Molecular Weight | 253.26 | Topological Polar Surface Area | 130 | ||
| Heavy Atom Count | 19 | Rotatable Bond Count | 1 | |||
| Hydrogen Bond Donor Count | 3 | Hydrogen Bond Acceptor Count | 7 | |||
| XLogP |
1
|
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| PubChem CID | ||||||
| PubChem SID |
118408
,602599
,855896
,933823
,5660597
,7847452
,8036221
,8149565
,8153414
,10321477
,11111878
,11111879
,11335608
,11360847
,11363402
,11365964
,11368526
,11372243
,11373970
,11376688
,11452214
,11461819
,11466062
,11467182
,11484612
,11485784
,11488754
,11491187
,11492181
,11494322
,14774401
,17389703
,17405750
,24277877
,26611958
,26679801
,26747035
,26751552
,29224587
,46507623
,47291080
,47588940
,47662218
,47662219
,47810690
,47885351
,47885352
,47959674
,48035047
,48334426
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| ChEBI ID |
CHEBI:9671
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | 1-Oct | Transporter Info | Organic cation transporter 1 | Substrate | [2] | |
| References | ||||||
| 1 | Triamterene was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. | |||||
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