Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01332
|
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| Drug Name |
Bromfenac
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| Synonyms |
2-Amino-3-(4-bromobenzoyl)benzeneacetic acid; 2-[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid; AHR-10282; BROMFENAC SODIUM; Bromfenac (INN); Bromfenac [INN]; Bromfenaco; Bromfenaco [Spanish]; Bromfenacum; Bromfenacum [Latin]; Duract; Duract (TN); Sodium 2-amino-3-(4-bromobenzoyl) phenylacetate sesquihydrate; Xibrom; Xibrom (TN); [2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid; [2-amino-3-(4-bromobenzoyl)phenyl]acetic acid; {2-amino-3-[(4-bromophenyl)carbonyl]phenyl}acetic acid
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| Drug Type |
Small molecular drug
|
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| Indication | Ocular pain [ICD11:MC18] | Approved | [1] | |||
| Ocular inflammation [ICD11:9C61.24] | Approved | [1] | ||||
| Therapeutic Class |
Antiinflammatory Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C15H12BrNO3
|
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| Canonical SMILES |
C1=CC(=C(C(=C1)C(=O)C2=CC=C(C=C2)Br)N)CC(=O)O
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| InChI |
InChI=1S/C15H12BrNO3/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19/h1-7H,8,17H2,(H,18,19)
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| InChIKey |
ZBPLOVFIXSTCRZ-UHFFFAOYSA-N
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| CAS Number |
CAS 91714-94-2
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| Pharmaceutical Properties | Molecular Weight | 334.16 | Topological Polar Surface Area | 80.4 | ||
| Heavy Atom Count | 20 | Rotatable Bond Count | 4 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 4 | |||
| XLogP |
3.3
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| PubChem CID | ||||||
| PubChem SID |
8187024
,14802056
,43118081
,46508121
,50065379
,50714597
,51091863
,53786963
,57288753
,57314080
,85433311
,103293849
,104321485
,117562408
,119526091
,125536482
,129879365
,131330262
,134338019
,135065652
,137005805
,142970983
,152227509
,160814551
,160964302
,162197012
,163089933
,163373042
,163837609
,164117525
,164175212
,172092503
,175268177
,178103707
,179151433
,184545820
,186004941
,196396861
,203081294
,204420653
,223388494
,223435566
,223484710
,223551046
,223656326
,224730616
,226420876
,242065764
,249847324
,250181405
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| ChEBI ID |
CHEBI:240107
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | OATP1B1 | Transporter Info | Organic anion transporting polypeptide 1B1 | Substrate | [2] | |
| References | ||||||
| 1 | Bromfenac was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs. J Pharmacol Exp Ther. 2018 Nov;367(2):322-334. | |||||
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