Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01326
|
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| Drug Name |
Thiamphenicol
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| Synonyms |
(+)-Thiamphenicol; 15318-45-3; Armai (TN); C12H15Cl2NO5S; D-Thiocymetin; D-Thiophenicol; Descocin; Dexawin; Dextrosulphenidol; EINECS 239-355-3; Efnicol; Hyrazin; Igralin; Macphenicol; Masatirin; Neomyson; RACEPHENICOL; Raceophenidol; Rincrol; SW 5063; Thiamcol; Thiamphenicol (Thiophenicol); Thiamphenicol [USAN:INN:BAN:JAN]; Thiamphenicolum; Thiamphenicolum [INN-Latin]; Thiocymetin; Thiocymetin (TN); Thiophenicol; Tiamfenicol [INN-Spanish]; Tiamfenicolo [DCIT]; UNII-FLQ7571NPM; Unaseran-D; Urfamicina; Urfamycine; WIN-5063-2; thiamphenicol
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infections [ICD11:1A00-1H0Z] | Approved | [1] | |||
| Sexually transmitted infections [ICD11:1A81, 1A9Y, 1A9Z] | Approved | [1] | ||||
| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C12H15Cl2NO5S
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| Canonical SMILES |
CS(=O)(=O)C1=CC=C(C=C1)C(C(CO)NC(=O)C(Cl)Cl)O
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| InChI |
InChI=1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1
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| InChIKey |
OTVAEFIXJLOWRX-NXEZZACHSA-N
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| CAS Number |
CAS 15318-45-3
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| Pharmaceutical Properties | Molecular Weight | 356.2 | Topological Polar Surface Area | 112 | ||
| Heavy Atom Count | 21 | Rotatable Bond Count | 6 | |||
| Hydrogen Bond Donor Count | 3 | Hydrogen Bond Acceptor Count | 5 | |||
| XLogP |
-0.3
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| PubChem CID | ||||||
| PubChem SID |
583242
,7848470
,8149922
,8169626
,10321825
,11336017
,11361256
,11364322
,11366884
,11369446
,11372663
,11374165
,11377608
,11462228
,11466053
,11467173
,11484607
,11485746
,11488672
,11491377
,11492548
,11495242
,14718432
,14876529
,14901130
,24899874
,26612415
,26680379
,34669745
,47216823
,47365241
,47365242
,47440309
,47662335
,47885462
,48110498
,48334547
,48414527
,48416608
,49698310
,49858850
,50122952
,50122953
,56320855
,56320856
,56435336
,56463332
,57310396
,75910232
,85788878
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| ChEBI ID |
ChEBI:32215
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | The Drugs.com International Drug Name Database: thiamphenicol | |||||
| 2 | Active Mediated Transport of Chloramphenicol and Thiamphenicol in a Calu-3 Lung Epithelial Cell Model. J Pharm Sci. 2018 Apr;107(4):1178-1184. | |||||
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