Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01286
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| Drug Name |
Pentazocine
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| Synonyms |
(2R*,6R*,11R*)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol; (2R,6R,11R)-6,11-dimethyl-3-(3-methylbut-2-en-1-yl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol; (2alpha,6alpha,11R*)-(1)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methylbut-2-enyl)-2,6-methano-3-benzazocin-8-ol; 1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol; 1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methylbut-2-enyl)-2,6-methano-3-benzazocin-8-ol; 2'-Hydroxy-5,9-dimethyl-2-(3,3-dimethylallyl)-6,7-benzomorphan; 2-(3,3-Dimethylallyl)-2',2'-hydroxy-5,9-dimethyl-6,7-benzomorphan; 2-(3,3-Dimethylallyl)cyclazocine; 2-Dimethylallyl-5,9-dimethyl-2'-hydroxybenzomorphan; 3-(3-Methyl-2-butenyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-2,6-methano-3-benzazocin-8-ol; Algopent (free base); Fortal (TN); Fortalgesic; Fortalin; Fortral; Fortral (TN); Fortwin (TN); II-C-2; KF-1820; L-pentazocine; Lexir; Liticon; NIH 7958; Pentagin; Pentazocaine; Pentazocin; Pentazocina; Pentazocina [DCIT]; Pentazocine (JP15/USP/INN); Pentazocine [USAN:INN:BAN:JAN]; Pentazocine, Pentazocin, Sosegon, WIN 20228; Pentazocinum; Pentazocinum [INN-Latin]; Sosegon; Soseton; Sosigon; Talacen; Talacen (TN); Talwan; Talwin (TN); Talwin NX (TN); Talwin PX (TN); WIN 20228
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| Drug Type |
Small molecular drug
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| Indication | Moderate to severe pain [ICD11:MG30-MG3Z] | Approved | [1] | |||
| Therapeutic Class |
Anesthetics
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| Structure |
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| 3D MOL | 2D MOL | |||||
| Formula |
C19H27NO
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| Canonical SMILES |
CC1C2CC3=C(C1(CCN2CC=C(C)C)C)C=C(C=C3)O
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| InChI |
InChI=1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3/t14-,18+,19+/m0/s1
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| InChIKey |
VOKSWYLNZZRQPF-GDIGMMSISA-N
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| CAS Number |
CAS 359-83-1
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| Pharmaceutical Properties | Molecular Weight | 285.4 | Topological Polar Surface Area | 23.5 | ||
| Heavy Atom Count | 21 | Rotatable Bond Count | 2 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 2 | |||
| XLogP |
3.3
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| PubChem CID | ||||||
| PubChem SID | ||||||
| ChEBI ID |
CHEBI:7982
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Pentazocine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. | |||||
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