Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01263
|
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| Drug Name |
Penciclovir
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| Synonyms |
2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3H-purin-6-one; 39809-25-1; 9-(4-HYDROXY-3-(HYDROXYMETHYL)BUT-1-YL)GUANINE; 9-(4-Hydroxy-3-(Hydroxymethyl)but-1-Yl)Guanine; 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine; 9-(4-hydroxy-3-hydroxymethylbut-1-yl)-guanine; 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine; 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine; BRL 39123; BRL-39123; CCRIS 9213; Denavir; Denavir (TN); PE2; Penciceovir; Penciclovir [USAN:INN:BAN]; Penciclovirum; Penciclovirum [INN-Latin]; Pencyclovir; UNII-359HUE8FJC; Vectavir; penciclovir
|
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| Drug Type |
Small molecular drug
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| Indication | Herpes simplex virus infection [ICD11:1F00] | Approved | [1] | |||
| Therapeutic Class |
Antiviral Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C10H15N5O3
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| Canonical SMILES |
C1=NC2=C(N1CCC(CO)CO)N=C(NC2=O)N
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| InChI |
InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)
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| InChIKey |
JNTOCHDNEULJHD-UHFFFAOYSA-N
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| CAS Number |
CAS 39809-25-1
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| Pharmaceutical Properties | Molecular Weight | 253.26 | Topological Polar Surface Area | 126 | ||
| Heavy Atom Count | 18 | Rotatable Bond Count | 5 | |||
| Hydrogen Bond Donor Count | 4 | Hydrogen Bond Acceptor Count | 5 | |||
| XLogP |
-1.9
|
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| PubChem CID | ||||||
| PubChem SID |
9621
,626312
,5433020
,7784770
,7889775
,7980269
,8152897
,12013576
,14774399
,15122289
,26719824
,26758052
,26759330
,29223811
,46386598
,46504797
,46506498
,47207082
,49681570
,50028164
,53800602
,57322416
,58107003
,76356225
,85246619
,91615544
,92308296
,92309147
,92710506
,103158227
,103567639
,104307247
,118046008
,118314778
,124658988
,124799997
,125349760
,126631814
,126658134
,126664331
,128301646
,131313494
,134213303
,134222457
,134337781
,135030805
,135260574
,137005929
,137035478
,141089745
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| ChEBI ID |
CHEBI:7956
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | OAT2 | Transporter Info | Organic anion transporter 2 | Substrate | [2] | |
| References | ||||||
| 1 | Penciclovir was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | In vitro studies with two human organic anion transporters: OAT2 and OAT7. Xenobiotica. 2018 Oct;48(10):1037-1049. | |||||
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