Drug Information

General Information
Drug ID
DR01211
Drug Name
Nimodipine
Synonyms
1,4-Dihydro-2,6-dimethyl-4-(3′-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester;1-methylethyl 2-(methyloxy)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 2-Methoxyethyl-1-methylethyl ester; 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-methoxyethyl 1-methylethyl ester; 3,5-pyridinecarboxylic acid 2-methoxyethyl 1-methylethyl ester; 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl), 2-methoxyethyl 1-methylethyl ester; 3-(2-methoxyethyl) 5-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 3-O-(2-methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide; Admon; Almirall Brand of Nimodipine; Alpharma Brand of Nimodipine; Andromaco Brand of Nimodipine; Bay-E 9736; Bay-e-9736; Bayer Brand of Nimodipine; Bayvit Brand of Nimodipine; Brainal; Calnit; Cantabria Brand of Nimodipine; DRG-0139; EG-1961; Elan Brand of Nimodipine; Esteve Brand of Nimodipine; Hexal Brand of Nimodipine; Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate; Kenesil; Modus; N-149; NIMOTOP (TN); NimoGel; Nimodipin Hexal; Nimodipin ISIS; Nimodipin-ISIS; NimodipinISIS; Nimodipine (USAN/INN); Nimodipine [USAN:BAN:INN]; Nimodipino; Nimodipino Bayvit; Nimodipino [INN-Spanish]; Nimodipinum; Nimodipinum [INN-Latin]; Nimotop; Nimotop (TN); Nimotop(TM); Nimotop, Nimodipine; Periplum; Periplum, Nimotop, BRN 0459792, DRG-0139; Remontal; Vita Brand of Nimodipine
Drug Type
Small molecular drug
Indication Cerebral vasospasm [ICD11:BA85.Z] Approved [1]
Therapeutic Class
Vasodilator Agents
Structure
3D MOL 2D MOL
Formula
C21H26N2O7
Canonical SMILES
CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC
InChI
InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
InChIKey
UIAGMCDKSXEBJQ-UHFFFAOYSA-N
CAS Number
CAS 66085-59-4
Pharmaceutical Properties Molecular Weight 418.4 Topological Polar Surface Area 120
Heavy Atom Count 30 Rotatable Bond Count 9
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 8
XLogP
3.1
PubChem CID
4497
PubChem SID
11119999 ,11120487 ,11120975 ,11121462 ,11121942 ,11147082 ,11341987 ,11362170 ,11362531 ,11364815 ,11365093 ,11367377 ,11367655 ,11369939 ,11370333 ,11370334 ,11371732 ,11373256 ,11374401 ,11375817 ,11378106 ,11466946 ,11468066 ,11485200 ,11486721 ,11487572 ,11489378 ,11490582 ,11492606 ,11495694 ,11528721 ,12013716 ,14831516 ,17405450 ,24277858 ,26612490 ,26663021 ,26680672 ,26747118 ,26747119 ,3153214 ,4444853 ,596563 ,6951262 ,7404101 ,7847504 ,7980128 ,8152770 ,855566 ,9476
ChEBI ID
CHEBI:7575
TTD Drug ID
D0XN1F
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
References
1 Nimodipine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.

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