Drug Information

General Information
Drug ID
DR01208
Drug Name
Eprosartan
Synonyms
(4-carboxybenzyl)imidazole-5-acrylic acid; (E)-2-Butyl-1-(p-carboxybenzyl)-alpha-2-thenylimidazole-5-acrylic acid; (E)-3-[2-n-butyl-1-{(4-carboxyphenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acid; (E)-4-((2-Butyl-5-(2-carboxy-3-(thiophen-2-yl)prop-1-en-1-yl)-1H-imidazol-1-yl)methyl)benzoic acid; (E)-alpha{[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazole-5-yl]methylene}-2-thiopheneproprionic acid; 133040-01-4; 2KH13Z0S0Y; 4-({2-butyl-5-[(1E)-2-carboxy-3-(2-thienyl)prop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid; 4-({2-butyl-5-[(1E)-2-carboxy-3-(thiophen-2-yl)prop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid; 4-[[2-butyl-5-[(E)-3-hydroxy-3-oxo-2-(thiophen-2-ylmethyl)prop-1-enyl]imidazol-1-yl]methyl]benzoic acid; CHEBI:4814; CHEMBL813; Eprosartan (USAN/INN); Eprosartan [USAN:BAN:INN]; F 108566; F-108566; SK&F 108566; SK&F-108566; SK-108566; SKF-108566; Teveten; Teveten (TN); UNII-2KH13Z0S0Y; [3H]eprosartan
Drug Type
Small molecular drug
Indication High blood pressure [ICD11:BA00] Approved [1]
Therapeutic Class
Antihypertensive Agents
Structure
3D MOL 2D MOL
Formula
C23H24N2O4S
Canonical SMILES
CCCCC1=NC=C(N1CC2=CC=C(C=C2)C(=O)O)C=C(CC3=CC=CS3)C(=O)O
InChI
InChI=1S/C23H24N2O4S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29)/b18-12+
InChIKey
OROAFUQRIXKEMV-LDADJPATSA-N
CAS Number
CAS 133040-01-4
Pharmaceutical Properties Molecular Weight 424.5 Topological Polar Surface Area 121
Heavy Atom Count 30 Rotatable Bond Count 10
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6
XLogP
4.5
PubChem CID
5281037
PubChem SID
103213560 ,103924435 ,113854438 ,117814116 ,121277912 ,126682167 ,127329712 ,127329713 ,127329714 ,127329715 ,127329716 ,127329717 ,127329718 ,127329719 ,127329720 ,127329721 ,127329722 ,127329723 ,131835100 ,134223577 ,134338185 ,135026481 ,135650236 ,136367951 ,137002491 ,142300349 ,144115951 ,14929623 ,162161427 ,163389404 ,164814942 ,17398013 ,175266444 ,176484078 ,26757976 ,39289969 ,46506765 ,48415948 ,49658621 ,49830795 ,50064350 ,50303490 ,7979177 ,81092802 ,85209073 ,8616481 ,91612944 ,92308966 ,93166188 ,9670
ChEBI ID
ChEBI:4814
TTD Drug ID
D0T7US
DT(s) Transporting This Drug PEPT1 Transporter Info Peptide transporter 1 Substrate [2]
References
1 Eprosartan was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9.

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