Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01194
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| Drug Name |
Cefotiam
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| Synonyms |
(6R,7R)-7-[2-(2-Amino-thiazol-4-yl)-acetylamino]-3-[1-(2-dimethylamino-ethyl)-1H-tetrazol-5-ylsulfanylmethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-(2-dimethylaminoethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}thio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7b-[2-(aminothiazol-4-yl)acetamido]-3-[[[1-(2-dimethylaminoethyl)-1h-tetrazol-5-yl]thio]methyl]ceph-3-em-4-carboxylic acid; 7beta-(2-amino-1,3-thiazol-4-yl)acetamido-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-3,4-didehydrocepham-4-carboxylic acid; Abbott-48999; Aspil; Aspil (TN); CEFOTIAM HYDROCHLORIDE; CGP 14221E; CGP-14221-E; CTM; Cefotiam (INN); Cefotiam [INN:BAN]; Cefotiamum; Cefotiamum [INN-Latin]; Ceradolan; Haloapor; SCE-963
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| Drug Type |
Small molecular drug
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| Indication | Fungal infections [ICD11:1F20-1F2Z] | Approved | [1] | |||
| Therapeutic Class |
Antibiotics
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C18H23N9O4S3
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| Canonical SMILES |
CN(C)CCN1C(=NN=N1)SCC2=C(N3C(C(C3=O)NC(=O)CC4=CSC(=N4)N)SC2)C(=O)O
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| InChI |
InChI=1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1
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| InChIKey |
QYQDKDWGWDOFFU-IUODEOHRSA-N
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| CAS Number |
CAS 61622-34-2
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| Pharmaceutical Properties | Molecular Weight | 525.6 | Topological Polar Surface Area | 251 | ||
| Heavy Atom Count | 34 | Rotatable Bond Count | 10 | |||
| Hydrogen Bond Donor Count | 3 | Hydrogen Bond Acceptor Count | 13 | |||
| XLogP |
-2.4
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| PubChem CID | ||||||
| PubChem SID |
103401140
,104343035
,11466510
,11467630
,11486000
,117600521
,124766419
,126670035
,134224539
,134338422
,135006449
,136054981
,137006379
,140253709
,143261064
,14763007
,14836521
,160963577
,163693587
,164788213
,174549096
,179150782
,196394354
,198976567
,223676320
,226515016
,236431513
,249865493
,251912556
,251916666
,252073508
,252358745
,34709097
,46506679
,47662540
,47811024
,47885651
,48334777
,48415723
,49699361
,50050897
,50124314
,50998350
,51091952
,8178318
,85547195
,85788073
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| ChEBI ID |
CHEBI:355510
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | OAT3 | Transporter Info | Organic anion transporter 3 | Substrate | [2] | |
| References | ||||||
| 1 | Cefotiam was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis. Am J Physiol Renal Physiol. 2008 Jul;295(1):F247-52. | |||||
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