Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01167
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| Drug Name |
Menadione
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| Synonyms |
Aquakay; 1,4-Naphthalenedione, 2-methyl-,radical ion(1-); 2-Methyl-1,4-naftochinon; 2-Methyl-1,4-naftochinon [Czech]; 2-Methyl-1,4-naphthalenedione; 2-Methyl-1,4-naphthochinon; 2-Methyl-1,4-naphthochinon [German]; 2-Methyl-1,4-naphthoquinone; 2-Methylnaphthoquinone; 2-methyl-1,4-naphthoquinone, 5; 2-methylnaphthalene-1,4-dione; 3-Methyl-1,4-naphthoquinone; 58-27-5; Aquakay; Aquinone; Ascorbic acid/menadione; Hemodal; Juva-K; K-Thrombyl; K-Vitan; Kaergona; Kanone; Kappaxan (VAN); Kappaxin; Kappaxin (TN); Karcon; Kareon; Kativ-G; Kayklot; Kaykot; Kayquinone; Kipca; Kipca, oil soluble; Kipca-Oil Soluble; Klottone; Klottone;Koaxin; Koaxin; Kolklot; M0373; Memodol; Menadion; Menadione (K3); Menadione (USP); Menadione [USAN:BAN]; Menadione semiquinone; Menadionum; Menaphthon; Menaphthone; Menaphtone; Menaquinone 0; Methyl-1,4-naphthalenedione; Methyl-1,4-naphthoquinone; Methylnaphthoquinone; Mitenon; Mitenone; Panosine; Prokayvit; Synkay; Thyloquinone; Triglycyl-lysine-vasopressin; Usaf; Usaf ek-5185; VK3; Vicasol; Vitamin K 3; Vitamin K0; Vitamin K2(0); Vitamin K3; Vitamin K3 : 2-Methyl-1,4-naphthoquinone; Vitamin-K3; menadione
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| Drug Type |
Small molecular drug
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| Indication | Vitamin K deficiency [ICD11:5B59] | Approved | [1] | |||
| Prostate cancer [ICD11:2C82] | Approved | [1] | ||||
| Therapeutic Class |
Vitamins
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C11H8O2
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| Canonical SMILES |
CC1=CC(=O)C2=CC=CC=C2C1=O
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| InChI |
InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
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| InChIKey |
MJVAVZPDRWSRRC-UHFFFAOYSA-N
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| CAS Number |
CAS 58-27-5
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| Pharmaceutical Properties | Molecular Weight | 172.18 | Topological Polar Surface Area | 34.1 | ||
| Heavy Atom Count | 13 | Rotatable Bond Count | 0 | |||
| Hydrogen Bond Donor Count | 0 | Hydrogen Bond Acceptor Count | 2 | |||
| XLogP |
2.2
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| PubChem CID | ||||||
| PubChem SID |
10321386
,10528213
,11112142
,11120351
,11120839
,11121327
,11335255
,11341462
,11360494
,11361645
,11364122
,11364936
,11366684
,11367498
,11369246
,11370060
,11373099
,11374123
,11375660
,11377408
,11378230
,11408337
,11446754
,11461466
,11466487
,11467607
,11485003
,11486213
,11487047
,11489010
,11492537
,11495042
,11532917
,11533196
,12016111
,14772598
,22389508
,24871411
,3133921
,607330
,6380040
,70547
,7751
,7849394
,7891061
,8136904
,8149919
,8152543
,853737
,853809
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| ChEBI ID |
ChEBI:28869
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | BCRP | Transporter Info | Breast cancer resistance protein | Substrate | [2] | |
| References | ||||||
| 1 | The Drugs.com International Drug Name Database: menadione | |||||
| 2 | The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3279-86. | |||||
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