Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR01032
|
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| Drug Name |
Metolazone
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| Synonyms |
2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide; 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide; Diulo; Metalazone; Metalozone; Metenix; Metolazona; Metolazona [INN-Spanish]; Metolazone (JAN/USP/INN); Metolazone [USAN:BAN:INN:JAN]; Metolazonum; Metolazonum [INN-Latin]; Microx; Mykrox; Mykrox (TN); Mykrox, Zaroxolyn, Diulo, Metolazone; Oldren; SR 720-22; SR-720-22; Xuret; Zaroxolyn; Zaroxolyn (TN)
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| Drug Type |
Small molecular drug
|
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| Indication | High blood pressure [ICD11:BA00] | Approved | [1] | |||
| Congestive heart failure [ICD11:BD10] | Approved | [1] | ||||
| Therapeutic Class |
Antihypertensive Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C16H16ClN3O3S
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| Canonical SMILES |
CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl
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| InChI |
InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
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| InChIKey |
AQCHWTWZEMGIFD-UHFFFAOYSA-N
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| CAS Number |
CAS 17560-51-9
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| Pharmaceutical Properties | Molecular Weight | 365.8 | Topological Polar Surface Area | 101 | ||
| Heavy Atom Count | 24 | Rotatable Bond Count | 2 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 5 | |||
| XLogP |
4.1
|
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| PubChem CID | ||||||
| PubChem SID |
10321392
,11335450
,11360689
,11363350
,11365912
,11368474
,11374036
,11376636
,11461661
,11466140
,11467260
,11485578
,11485799
,11489557
,11492044
,11494270
,14926227
,24724532
,26613200
,26680432
,26747536
,26747537
,26753589
,26753590
,29223276
,46509058
,47365083
,47365084
,47588891
,47736365
,47736366
,47885305
,48259128
,4904668
,49698717
,50041173
,50106417
,50106418
,50267110
,56413187
,56463247
,56463561
,57322175
,7847497
,7979975
,8150176
,8152610
,85087884
,85787877
,90341106
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| ChEBI ID |
CHEBI:64354
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | NCC | Transporter Info | Thiazide-sensitive sodium-chloride cotransporter | Substrate | [2] | |
| References | ||||||
| 1 | Metolazone was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Inhibition of binding of [3H]metolazone to rat kidney membrane by stilbene disulfonates. Biochem Pharmacol. 1991 Jun 1;41(11):1745-50. | |||||
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