Drug Information

General Information
Drug ID
DR00717
Drug Name
Cordycepin
Synonyms
3'-deoxyadenosine
Drug Type
Small molecular drug
Indication Leukemia [ICD11:2A60-2B33] Phase 1 [1]
Structure
3D MOL 2D MOL
Formula
C10H13N5O3
Canonical SMILES
C1C(OC(C1O)N2C=NC3=C(N=CN=C32)N)CO
InChI
InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1
InChIKey
OFEZSBMBBKLLBJ-BAJZRUMYSA-N
CAS Number
CAS 73-03-0
Pharmaceutical Properties Molecular Weight 251.24 Topological Polar Surface Area 119
Heavy Atom Count 18 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
XLogP
-1.2
PubChem CID
6303
PubChem SID
103129788 ,103273186 ,104033937 ,104311670 ,10626 ,117523233 ,124800800 ,125011547 ,126623062 ,126677967 ,128800334 ,134972791 ,137147501 ,143236593 ,143490941 ,14823463 ,151994294 ,152041673 ,152165446 ,15221211 ,152240358 ,162138340 ,162188736 ,162221036 ,163109850 ,163391174 ,176267097 ,178101348 ,24892611 ,29225295 ,46484863 ,46484864 ,47193882 ,48253971 ,48404485 ,49865089 ,56312866 ,57323332 ,57390369 ,57581404 ,596772 ,66571172 ,77990435 ,7885247 ,8153975 ,838940 ,85177286 ,91692846 ,95153093 ,99452995
ChEBI ID
CHEBI:29014
TTD Drug ID
D0Q9MA
DT(s) Transporting This Drug ENT3 Transporter Info Equilibrative nucleoside transporter 3 Substrate [2]
Drug-Transporter Activity Data
Drug-Transporter Activity Data ENT3 Transporter Info Km =1860 microM Xenopus Oocytes-ENT3 [2]
References
1 ClinicalTrials.gov (NCT00003005) Chemotherapy With Cordycepin Plus Pentostatin in Treating Patients With Refractory Acute Lymphocytic or Chronic Myelogenous Leukemia
2 Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem. 2005 Apr 22;280(16):15880-7.

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