Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00709
|
|||||
| Drug Name |
Bepridil
|
|||||
| Synonyms |
Bepadin; Bepadin (TN); Bepridil (INN); Beta-((2-Methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine; CERM 1978; N-Benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-yl-propyl]aniline hydrochloride; N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline; N-benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline; N-{3-[(2-methylpropyl)oxy]-2-pyrrolidin-1-ylpropyl}-N-(phenylmethyl)aniline; Vascor; Vascor (TN)
|
|||||
| Drug Type |
Small molecular drug
|
|||||
| Indication | Chronic stable angina [ICD11:BA40] | Approved | [1] | |||
| Therapeutic Class |
Antiarrhythmic Agents
|
|||||
| Structure |
|
 |
||||
| 3D MOL | 2D MOL | |||||
| Formula |
C24H34N2O
|
|||||
| Canonical SMILES |
CC(C)COCC(CN(CC1=CC=CC=C1)C2=CC=CC=C2)N3CCCC3
|
|||||
| InChI |
InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3
|
|||||
| InChIKey |
UIEATEWHFDRYRU-UHFFFAOYSA-N
|
|||||
| CAS Number |
CAS 64706-54-3
|
|||||
| Pharmaceutical Properties | Molecular Weight | 366.5 | Topological Polar Surface Area | 15.7 | ||
| Heavy Atom Count | 27 | Rotatable Bond Count | 10 | |||
| Hydrogen Bond Donor Count | 0 | Hydrogen Bond Acceptor Count | 3 | |||
| XLogP |
5.3
|
|||||
| PubChem CID | ||||||
| PubChem SID |
11120268
,11120756
,11121244
,11121366
,11121846
,11335285
,11360524
,11362435
,11364639
,11364997
,11367201
,11367559
,11369763
,11370141
,11370142
,11371654
,11373160
,11374413
,11375721
,11377925
,11461496
,11466396
,11467516
,11484478
,11486152
,11488717
,11490563
,11492612
,11495559
,14755108
,24262992
,26755663
,26755664
,29221519
,46506353
,47217021
,47217022
,47217023
,47440509
,47736734
,47811007
,47811008
,48035374
,48035375
,48035376
,48110710
,5424488
,7978773
,8151577
,9065
|
|||||
| ChEBI ID |
ChEBI:3061
|
|||||
| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Bepridil was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. | |||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.