Drug Information

General Information
Drug ID
DR00707
Drug Name
Trichloromethiazide
Synonyms
(+-)-6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-,1,1-dioxide; 3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; 3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide; 3-Dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide; 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide; 3-Dichloromethylhydrochlorothiazide; 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide; 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide; 6-Chloro-3-[dichloromethyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide; 6-Chloro-3-dichloromethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide; 6-Chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide; Achletin; Achletin (TN); Anistadin; Aponorin; Aquazide; Carvacron; Chlopolidine; Ciba 7057-Su; Cretonin; Diu-Hydrin; Diu-Hydrin (TN); Diurazida; Diurese; Diuroral;Esmarin; Eurinol; Fluitran; Flurese; Flurese (VAN); Flutra; Gangesol; Hydrotrichlorothiazide; Intromene; Isestran; Jones Brand of Trichloromethiazide; Kubacron; Metahydrin; Metatensin; Nakva; Naqua; Naqua (TN); Naquasone; Salurin (wadel); Schebitran; Schering Brand of Trichlormethiazide; Tachionin; Tolcasone; Trichlordiuride; Trichlorex; Trichlormas; Trichlormetazid; Trichlormethiazid; Trichlormethiazide (JP15/USP/INN); Trichlormethiazide W/ Reserpine; Trichlormethiazide [INN:JAN]; Trichlormethiazidum; Trichlormethiazidum [INN-Latin]; Trichloromethiadiazide; Trichloromethiazide; Trichloromethiazide, 6; Triclordiuride; Triclormetiazida; Triclormetiazida[INN-Spanish]; Triclormetiazide; Triclormetiazide [DCIT]; Triclormetiazide [Italian]; Triflumen (TN); Triflumen;American Urologicals Brand of Trichloromethiazide
Drug Type
Small molecular drug
Indication Edema associated with heart failure [ICD11:BD10.Z] Approved [1]
Therapeutic Class
Antihypertensive Agents
Structure
3D MOL 2D MOL
Formula
C8H8Cl3N3O4S2
Canonical SMILES
C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)NC(N2)C(Cl)Cl
InChI
InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
InChIKey
LMJSLTNSBFUCMU-UHFFFAOYSA-N
CAS Number
CAS 133-67-5
Pharmaceutical Properties Molecular Weight 380.7 Topological Polar Surface Area 135
Heavy Atom Count 20 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
XLogP
0.6
PubChem CID
5560
PubChem SID
10321929 ,10506863 ,108999 ,11335541 ,11360780 ,11363414 ,11365976 ,11368538 ,11372245 ,11373972 ,11376700 ,11455198 ,11461752 ,11466853 ,11467973 ,11484652 ,11486406 ,11488764 ,11491188 ,11492182 ,11494334 ,14780142 ,24899924 ,26611959 ,26747211 ,26747212 ,29224600 ,46508880 ,47440176 ,47588924 ,47662203 ,47810669 ,47885335 ,47885336 ,48110377 ,48416658 ,49698743 ,49890376 ,53789117 ,56422224 ,5663656 ,57298708 ,57322840 ,597352 ,7847724 ,80830904 ,8149566 ,8153417 ,855703 ,9969
ChEBI ID
CHEBI:9683
TTD Drug ID
D0Y2IZ
DT(s) Transporting This Drug OAT3 Transporter Info Organic anion transporter 3 Substrate [2]
References
1 Trichloromethiazide was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8.

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