Drug Information

General Information
Drug ID
DR00691
Drug Name
Felodipine
Synonyms
(+-)-Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate; (+/-)-ethylmethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate; 1A Brand of Felodipine; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2,6-dimethyl-, ethyl methylester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2,6-dimethyl-,ethyl methyl ester; 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester; 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate; 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester; 4-(2,3-dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester; 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester; 5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; AE-641/11429675; AGON SR; AbZ Brand of Felodipine; Agon; Aliud Brand of Felodipine; Alphapharm Brand of Felodipine; Alpharma Brand of Felodipine; Astra Brand of Felodipine; AstraZeneca Brand of Felodipine; Aventis Brand of Felodipine; Azupharma Brand of Felodipine; BC Brand of Felodipine; Betapharm Brand of Felodipine; CGH-869; Ct Arzneimittel Brand of Felodipine; Ct-Arzneimittel Brand of Felodipine; Dl-Felodipine; Ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; F 9677; Felo Biochemie; Felo Puren; Felo-Puren; Felobeta; Felocor; Feloday; Felodipin 1A Pharma; Felodipin AL; Felodipin AZU; Felodipin AbZ; Felodipin Heumann; Felodipin Stada; Felodipin dura; Felodipin ratiopharm; Felodipin von ct; Felodipin-ratiopharm; Felodipina; Felodipina [INN-Spanish]; Felodipine (JAN/USP/INN); Felodipine [USAN:BAN:INN]; Felodipine [USAN:INN:BAN]; Felodipinum; Felodipinum [INN-Latin]; Felodur; FelodurER; Felogamma; Felogard; Fensel; Flodil; H 154 82; H 154-82; H 154/82; H 15482; H-154/82; Heumann Brand of Felodipine; Heumann, Felodipin; Hexal Brand of Felodipine; Hoechst Brand of Felodipine; Hydac; Lexxel; Logimax; Merck dura Brand of Felodipine; Modip; Munobal; Munobal Retard; Penedil; Perfudal; Pharmaceutica Astra Brand of Felodipine; Pharmacia Spain Brandof Felodipine; Plandil; Plendil; Plendil (TN); Plendil Depottab; Plendil ER; Plendil Retard; Plendil, Renedil, Feloday, Felodipine; Preslow; Prevex; Promed Brand of Felodipine; Ratiopharm Brand of Felodipine; Renedil; Splendil; Stadapharm Brand of Felodipine; TheraPharm Brand of Felodipine; Worwag Brand of Felodipine
Drug Type
Small molecular drug
Indication High blood pressure [ICD11:BA00] Approved [1]
Therapeutic Class
Antihypertensive Agents
Structure
3D MOL 2D MOL
Formula
C18H19Cl2NO4
Canonical SMILES
CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
InChI
InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKey
RZTAMFZIAATZDJ-UHFFFAOYSA-N
CAS Number
CAS 72509-76-3
Pharmaceutical Properties Molecular Weight 384.2 Topological Polar Surface Area 64.599
Heavy Atom Count 25 Rotatable Bond Count 6
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5
XLogP
3.9
PubChem CID
3333
PubChem SID
103024636 ,10321744 ,103543150 ,103856247 ,103914230 ,104170219 ,104253409 ,11466506 ,11467626 ,11486291 ,11528719 ,12012613 ,14927301 ,16960569 ,17405071 ,24278449 ,29222468 ,46506968 ,47509540 ,47656605 ,47879634 ,48179244 ,48328566 ,48416001 ,49698512 ,50106289 ,50106290 ,5309057 ,53777614 ,53788382 ,56423042 ,56424130 ,56463217 ,56463516 ,57321731 ,78292296 ,7847385 ,7979219 ,8152117 ,85231057 ,856004 ,85788575 ,87351806 ,90340828 ,92125582 ,92303867 ,92308861 ,92711325 ,93166891 ,99453448
ChEBI ID
CHEBI:585948
TTD Drug ID
D0WN0U
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
References
1 Felodipine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 The influence of CYP3A5*3 and BCRPC421A genetic polymorphisms on the pharmacokinetics of felodipine in healthy Chinese volunteers. J Clin Pharm Ther. 2017 Jun;42(3):345-349.

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