Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00689
|
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| Drug Name |
Carvedilol
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| Synonyms |
(+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol; (+-)-1-Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol; (+/-)-1-(Carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol; 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol; 1-(9H-carbazol-4-yloxy)-3-[(2-{[2-(methyloxy)phenyl]oxy}ethyl)amino]propan-2-ol; 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol; 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol; Artist; Artist (TN); Atlana Pharma brand of carvedilol; BM 14190; BM-14-190; BM-14.190; BM-14190; Carloc (TN); Carvedilol (JAN/USAN/INN); Carvedilol [USAN:INN:BAN:JAN]; Carvedilol, (+-)-isomer; Carvedilol, (R)-isomer; Carvedilol, (S)-isomer; Carvedilol, 14C-labeled; Carvedilolum; Carvedilolum [Latin]; Coreg; Coreg (TN); Coreg CR; Coropres; Coropress; DQ 2466; DQ-2466; Dibloc; Dilatrend; Dilatrend (TN); EG-P042; Eucardic; Eucardic (TN); GlaxoSmithKline brand of carvedilol; Kredex; Lakeside brand of carvedilol; Querto; Roche brand of carvedilol; SK&F-105517; SKF 105517
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| Drug Type |
Small molecular drug
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| Indication | Congestive heart failure [ICD11:BD10] | Approved | [1] | |||
| Therapeutic Class |
Vasodilator Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C24H26N2O4
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| Canonical SMILES |
COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O
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| InChI |
InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
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| InChIKey |
OGHNVEJMJSYVRP-UHFFFAOYSA-N
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| CAS Number |
CAS 72956-09-3
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| Pharmaceutical Properties | Molecular Weight | 406.5 | Topological Polar Surface Area | 75.7 | ||
| Heavy Atom Count | 30 | Rotatable Bond Count | 10 | |||
| Hydrogen Bond Donor Count | 3 | Hydrogen Bond Acceptor Count | 5 | |||
| XLogP |
4.2
|
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| PubChem CID | ||||||
| PubChem SID |
103197484
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,11367121
,11369683
,11372422
,11374391
,11377845
,11485621
,11489489
,11490997
,11492451
,11495479
,11528712
,12013067
,14855122
,26719722
,26719723
,29221745
,46386749
,46386871
,46505146
,47805057
,48415707
,49681735
,49834917
,50112972
,50112973
,53789407
,56313592
,56413047
,56464135
,57321386
,7387304
,76450239
,7847321
,7978866
,81040900
,81092790
,8151709
,85209910
,85789499
,85789708
,87560280
,90341342
,9092
,92251378
,92307922
,92308493
,92308705
,92711411
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| ChEBI ID |
ChEBI:3441
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Carvedilol was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. | |||||
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