Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00684
|
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| Drug Name |
Midazolam
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| Synonyms |
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate; 8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin; 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine; 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride; 8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine; 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine; Dazolam; Dormicum; Dormicum (TN); Hypnovel (TN); Midacum (TN); Midanium; Midazolam (JAN/INN); Midazolam Base; Midazolam [INN:BAN:JAN]; Midazolamum; Midazolamum [INN-Latin]; Midosed; Ro 21-3981; Versed; Versed (TN)
|
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| Drug Type |
Small molecular drug
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| Indication | Seizure [ICD11:8A68] | Approved | [1] | |||
| Therapeutic Class |
Hypnotics and Sedatives
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C18H13ClFN3
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| Canonical SMILES |
CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F
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| InChI |
InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3
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| InChIKey |
DDLIGBOFAVUZHB-UHFFFAOYSA-N
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| CAS Number |
CAS 59467-70-8
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| Pharmaceutical Properties | Molecular Weight | 325.8 | Topological Polar Surface Area | 30.2 | ||
| Heavy Atom Count | 23 | Rotatable Bond Count | 1 | |||
| Hydrogen Bond Donor Count | 0 | Hydrogen Bond Acceptor Count | 3 | |||
| XLogP |
2.5
|
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| PubChem CID | ||||||
| PubChem SID |
103189248
,104305695
,10528812
,126628994
,126644317
,126685927
,126723172
,127718929
,134337555
,135006020
,137003028
,140030431
,14850779
,151981999
,160964028
,163414843
,164763056
,164814508
,175265628
,178100372
,179116788
,198991796
,210279804
,210282127
,223440338
,223675382
,224544524
,226421396
,241102041
,24724654
,250117805
,252088595
,29223297
,46507611
,48416279
,49689435
,49833675
,49978815
,50113067
,50371480
,53789031
,57322185
,7433688
,7847616
,7849648
,7979987
,8152621
,92716937
,93166805
,9727
|
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| ChEBI ID |
CHEBI:6931
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Midazolam was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. | |||||
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