Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00672
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| Drug Name |
Emtricitabine
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| Synonyms |
(-)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; (-)-.beta.-L-FTC; (-)-2',3'-Dideoxy-5-fluoro-3'-thiacytidine; (-)-2'-Deoxy-5-fluoro-3'-thiacytidine; (-)-FTC; (-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine; (-)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one; (2R-cis)-4-Amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone; 1-(2-(Hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine; 2',3',5-FTC; 2',3'-Dideoxy-5-fluoro-3'-thiacytidine; 2'-Deoxy-5-fluoro-3'-oxa-4'-thiocytidine; 2'-Deoxy-5-fluoro-3'-thiacytidine; 2-FTC; 3'-Thia-2'.3'-dideoxy-5-fluorocytidine; 4-Amino-5-fluoro-1-[(2R,5S)-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone; 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one; 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one; 5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine; 5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine; 5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)[1,3]oxathiolan-5-yl]cytosine; 524W91; BW 1592; BW 524W91; BW-524W91; BW524W91; Beta-L-(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; Beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine; Coviracil; Coviracil (TN); Coviracil(TM); DOTFC; DRG-0208; Emtricitabine (JAN/USAN/INN); Emtriva; Emtriva(TM); FTC; RCV; Racivir
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| Drug Type |
Small molecular drug
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| Indication | Hepatitis B virus infection [ICD11:1E51.0, 1E50.1] | Approved | [1] | |||
| Human immunodeficiency virus infection [ICD11:1C62.Z] | Approved | [1] | ||||
| Therapeutic Class |
Anti-HIV Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C8H10FN3O3S
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| Canonical SMILES |
C1C(OC(S1)CO)N2C=C(C(=NC2=O)N)F
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| InChI |
InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1
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| InChIKey |
XQSPYNMVSIKCOC-NTSWFWBYSA-N
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| CAS Number |
CAS 143491-57-0
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| Pharmaceutical Properties | Molecular Weight | 247.25 | Topological Polar Surface Area | 113 | ||
| Heavy Atom Count | 16 | Rotatable Bond Count | 2 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 5 | |||
| XLogP |
-0.6
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| PubChem CID | ||||||
| PubChem SID |
103232542
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,127310207
,127310208
,129727356
,134223773
,134338341
,135018286
,135022892
,135590997
,136947986
,137006539
,142372786
,144205746
,14749730
,14847619
,151992517
,152034369
,160826182
,160964220
,162792750
,163388307
,163621100
,24875080
,26757984
,43118210
,46507606
,48424313
,49830960
,50064421
,57314168
,582989
,600446
,71814561
,76230216
,7848262
,8187110
,92308841
,92729801
,99313695
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| ChEBI ID |
CHEBI:31536
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | MATE1 | Transporter Info | Multidrug and toxin extrusion protein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Emtricitabine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Emtricitabine is a substrate of MATE1 but not of OCT1, OCT2, P-gp, BCRP or MRP2 transporters. Xenobiotica. 2017 Jan;47(1):77-85. | |||||
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