Drug Information

General Information
Drug ID
DR00668
Drug Name
Nisoldipine
Synonyms
(+-)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester; 3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Bay k 5552; Bay-k-5552; Baymycard; Isobutyl 1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridincarboxylat;Methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Nisocor; Nisoldipin; Nisoldipine (JAN/USAN/INN); Nisoldipine [USAN:BAN:INN:JAN]; Nisoldipino; Nisoldipino [INN-Spanish]; Nisoldipinum; Nisoldipinum [INN-Latin]; Sular; Sular (TN); Syscor; Zadipina
Drug Type
Small molecular drug
Indication High blood pressure [ICD11:BA00] Approved [1]
Therapeutic Class
Antihypertensive Agents
Structure
3D MOL 2D MOL
Formula
C20H24N2O6
Canonical SMILES
CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
InChI
InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
InChIKey
VKQFCGNPDRICFG-UHFFFAOYSA-N
CAS Number
CAS 63675-72-9
Pharmaceutical Properties Molecular Weight 388.4 Topological Polar Surface Area 110
Heavy Atom Count 28 Rotatable Bond Count 7
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 7
XLogP
3.3
PubChem CID
4499
PubChem SID
103219831 ,103680984 ,104306583 ,11528722 ,117875317 ,118048486 ,12012773 ,121363368 ,124658895 ,124799896 ,125355226 ,126630843 ,126657331 ,126665640 ,131322121 ,131846259 ,134337886 ,135004762 ,135650722 ,135692260 ,137122027 ,137349418 ,139157574 ,14780577 ,26719878 ,26758055 ,29223593 ,46386699 ,46504546 ,48416330 ,49681768 ,5054384 ,53787999 ,56313694 ,56463094 ,57322301 ,6595685 ,6951250 ,7594280 ,7847684 ,7980129 ,80626920 ,81092916 ,8152772 ,92307945 ,92308528 ,92308896 ,92711446 ,93166842 ,9901
ChEBI ID
CHEBI:76917
TTD Drug ID
D0S5CU
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
References
1 Nisoldipine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.

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