Drug Information

General Information
Drug ID
DR00665
Drug Name
Atropine
Synonyms
(+,-)-Tropyl tropate; (+-)-atropine; (+-)-hyoscyamine; (+/-)-Atropine; (+/-)-Hyoscyamine; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol; (3-endo,8-syn)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-azoniabicyclo[3.2.1]octane; (3-exo)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol; 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester); 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester) (8CI); 1alphaH,5alphaH-Tropan-3alpha-ol; 1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester); 1alphaH,5alphaH-Tropan-3beta-ol; 2-Phenylhydracrylic acid 3-alpha-tropanyl ester; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; 8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropionate; A-Tropine; Anaspaz; Atropair; Atropen; Atropen (TN); Atropin; Atropin [German]; Atropin-flexiolen; Atropina; Atropina [Italian]; Atropine (USP); Atropine Care; Atropine Sulfate S.O.P.; Atropine [BAN]; Atropinium cation; Atropinium(1+); Atropinol; Atropt; Atrosulf; B eta-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; Belladenal; Bellergal-S; Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; Beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester [German]; Beta-Phenyl-gamma-oxypropionsaure-tropyl-ester [German]; Cytospaz; D1-hyoscyamine; DL-Tropanyl 2-hydroxy-1-phenylpropionate; DL-Tropyl tropate; Dl-Hyoscyamine; Dl-Tropyltropate; Endo-(+/-)-alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; Endo-8-methyl-8-azabicyclo[3.2.1]octan-3-ol; Eyesules; Hyoscyamine; Hyoscyamine sulfate; I-Tropine; Isopto Atropine; Isopto-atropine; Lomotil (TN); Minims; Minims Atropine; NP-010662; Neo-Diophen; OR22908; Ocu-Tropine; Protamine & Atropine; Tropan-3alpha-ol; Tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate; Tropan-3beta-ol; Tropanol; Tropic acid, 3-alpha-tropanyl ester; Tropic acid, ester with tropine; Tropine (+/-)-tropate; Tropine tropate; Tropine, tropate (ester); Troyl tropate; Urised; [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate
Drug Type
Small molecular drug
Indication Poison intoxication [ICD11:NE6Z] Approved [1]
Therapeutic Class
Antiarrhythmic Agents
Structure
3D MOL 2D MOL
Formula
C17H23NO3
Canonical SMILES
CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
InChI
InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16?
InChIKey
RKUNBYITZUJHSG-PJPHBNEVSA-N
CAS Number
CAS 51-55-8
Pharmaceutical Properties Molecular Weight 289.4 Topological Polar Surface Area 49.8
Heavy Atom Count 21 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4
XLogP
1.8
PubChem CID
174174
PubChem SID
10258016 ,104098724 ,104169991 ,104171350 ,111677788 ,113474904 ,11533003 ,117475976 ,118260686 ,121362578 ,124558762 ,124799783 ,124883031 ,124883032 ,124883033 ,124883034 ,129143706 ,131408727 ,134337687 ,16376693 ,24890401 ,24890659 ,26754302 ,29215197 ,33498346 ,36511844 ,46476231 ,46507540 ,4651 ,47359794 ,48253833 ,48413242 ,48415591 ,49857189 ,53789078 ,56313665 ,56422449 ,57352393 ,75150730 ,7837579 ,7847181 ,7978742 ,814306 ,8144950 ,841226 ,85788924 ,85856317 ,92308692 ,93576972 ,95156767
ChEBI ID
ChEBI:16684
TTD Drug ID
D0RG3O
DT(s) Transporting This Drug 1-Oct Transporter Info Organic cation transporter 1 Substrate [2]
References
1 Atropine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42.

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