Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00636
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| Drug Name |
Reserpine
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| Synonyms |
3P Reserp; Abesta; Abicol; Adelfan; Adelphin; Alkarau; Alkaserp; Alserin; Apoplon; Apoplon (TN); Apsical; Ascoserp; Ascoserpina; Austrapine; Banasil; Banisil; Benazyl; Bioserpine; Brinderdin; Briserine; Broserpine; Cam-Ap-Es; Cardioserpin; Carditivo; Carpacil; Carrserp; Darebon; Deserpine; Diupres 250; Diupres 500; Diupres-250; Diupres-500; Diurese-R; Diutensen-R; Dralserp; ENT 50146; Eberpine; Eberspine; Ebserpine; Elfanex; Elserpine; Enipresser; Esc aspere; Escaspere; Eserpine; Eskaserp; Eskaserpine; Gammaserpine; Gilucard; H 520; HYDRO-RESERP; Helfoserpin; Hexaplin; Hiposerpil; Hiserpia; Hydrap-ES; Hydromox R; Hydromox-R; Hydropine; Hydropres 25; Hydropres 50; Hydroserp; Hydrosine 25; Hypercal B; Hypersil; Hypersine; Hypertensan; Idoserp; Idsoserp; Interpina; Key-serpine; Kitine; Klimanosid; L"-Carpserp; L-Carpserp; Lemiserp; Loweser p; Loweserp; Mallopress; Maviserpin; Mayserpine; Mephaserpin; Modenol; Naquival; Nembuserpin; Neo-serp; Neose rfin; Neoserfin; Neoserp; Neoslowten; Orthoserpina; Perskleran; Pressimedin; Purserpine; Quiescin; R 0875; R-e-s; Rau sedyl; Rau-Sed; Raucap; Raudiford; Raudixin; Raudixoid; Raugal; Raulen; Rauloydin; Raumorine; Raunervil; Raunorine; Raunova; Raupasil; Raupoid; Raurine; Rausan; Rausedan; Rausedil; Rausedyl; Rauserpin; Rauserpine; Rauserpol; Rausingle; Rautrin; Rauvlid; Rauwasedin; Rauwilid; Rauwiloid; Rauwipur; Rauwita; Rauwoleaf; Rawilid; Recipin; Regroton; Renese R; Renese-R; Resaltex; Rese rpamed; Rese-lar; Resedrex; Resedril; Reser-ar; Reserbal; Resercaps; Resercen; Reserfia; Reserjen; Reserlor; Reserp; Reserpal; Reserpamed; Reserpanca; Reserpene; Reserpex; Reserpidefe; Reserpil; Reserpin; Reserpina; Reserpinum; Reserpka; Reserpoid; Reserpur; Reserutin; Resiatric; Residin; Residine; Resine; Resocalm; Resperin; Resperine; Respital; Restran; Rezerpin; Riserpa; Rivased; Rivasin; Rolserp; Roxel; Roxinoid; Roxynoid; Ryser; SK-Reserpine; Salupres; Sandril; Sandron; Se rpate; Sedaraupin; Sedaraupina; Sederaupin; Sedserp; Seominal; Ser-A-Gen; Serfin; Serfolia; Serolfia; Serpalan; Serpaloid; Serpaneurona; Serpanray; Serpasil; Serpasol; Serpate; Serpazil; Serpazol; Serpedin; Serpen; Serpena; Serpentil; Serpentin; Serpentina; Serpicon; Serpil; Serpiloid; Serpilum; Serpine; Serpipur; Serpivate; Serpivite; Serpogen; Serpoid; Serpone; Serpyrit; Sertabs; Sertens; Sertensin; Sertina; Supergan; T-Serp; Tefaserpina; Temposerpine; Tensanyl; Tenserpinie; Tensional; Tensionorme; Tepserpine; Terbolan; Transerpin; Triserpin; Tylandril; Unilord; Unipres; Usaf cb-27; V Serp; V-Serp; VI XO; VIXO; Veriloid; Vio-Serpine
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| Drug Type |
Small molecular drug
|
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| Indication | High blood pressure [ICD11:BA00] | Approved | [1] | |||
| Therapeutic Class |
Antihypertensive Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C33H40N2O9
|
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| Canonical SMILES |
COC1C(CC2CN3CCC4=C(C3CC2C1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
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| InChI |
InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
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| InChIKey |
QEVHRUUCFGRFIF-MDEJGZGSSA-N
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| CAS Number |
CAS 50-55-5
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| Pharmaceutical Properties | Molecular Weight | 608.7 | Topological Polar Surface Area | 118 | ||
| Heavy Atom Count | 44 | Rotatable Bond Count | 10 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 10 | |||
| XLogP |
4
|
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| PubChem CID | ||||||
| PubChem SID |
10321248
,107574
,11335187
,11360426
,11362963
,11365525
,11368087
,11371907
,11374535
,11376249
,11408836
,11461398
,11466903
,11468023
,11486606
,11490709
,11492803
,11493923
,11528314
,134033
,14887357
,16543090
,17389743
,17404636
,24278208
,24888118
,25622640
,26611910
,26697044
,26752948
,29224805
,3134366
,46505863
,47213181
,47440061
,47810577
,47885233
,47959555
,47959556
,47959557
,48110277
,48334297
,48334298
,48414422
,623918
,7847265
,8138322
,8149518
,8153544
,8769
|
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| ChEBI ID |
ChEBI:28487
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | BCRP | Transporter Info | Breast cancer resistance protein | Substrate | [2] | |
| P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [3] | ||
| References | ||||||
| 1 | Reserpine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. | |||||
| 3 | Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. | |||||
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