Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00629
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| Drug Name |
Aldosterone
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| Synonyms |
(+)-Aldosterone; (11BETA)-11,21-DIHYDROXY-3,20-DIOXOPREGN-4-EN-18-AL; (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde; 11.beta.,21-Dihydroxypregn-4-ene-3,18,20-trione; 11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al; 11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al; 11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al; 11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 18,11-halbacetal; 11beta,21-Dihydroxypregn-4-ene-3,18,20-trione; 11beta,21-dihydroxy-3,20-dioxo-pregn-4-ene-18-al; 11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al; 18-Aldocorticosterone; 18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione; 18-Oxocorticosterone; Aldocorten; Aldocortene; Aldocortin; Aldosterona; Aldosterona [INN-Spanish]; Aldosterone [INN:BAN:DCF]; Aldosterone, (+-)-Isomer; Aldosterone, (11 beta,17 alpha)-Isomer; Aldosteronum; Aldosteronum [INN-Latin]; D-Aldosterone; Electrocortin; Elektrocortin; Reichstein X
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| Drug Type |
Small molecular drug
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| Indication | High blood pressure [ICD11:BA00] | Approved | [1] | |||
| Therapeutic Class |
Antihypertensive Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C21H28O5
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| Canonical SMILES |
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O
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| InChI |
InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
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| InChIKey |
PQSUYGKTWSAVDQ-ZVIOFETBSA-N
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| CAS Number |
CAS 52-39-1
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| Pharmaceutical Properties | Molecular Weight | 360.4 | Topological Polar Surface Area | 91.7 | ||
| Heavy Atom Count | 26 | Rotatable Bond Count | 3 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 5 | |||
| XLogP |
1.1
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| PubChem CID | ||||||
| PubChem SID |
103174056
,104310406
,115922
,12146619
,123120918
,124800418
,126666510
,128954713
,134338558
,134972910
,135651432
,137048176
,141345016
,14828271
,160967623
,163076031
,172097284
,175268093
,178100450
,24702310
,24891458
,26757653
,29224871
,3139122
,46505770
,48415527
,48421925
,4910
,50019585
,53789139
,56310979
,56311296
,56311417
,56312971
,56313892
,56314372
,56320629
,56320630
,57322992
,57392512
,625873
,77125022
,7885975
,7978658
,8144488
,8153606
,841789
,85845809
,87219227
,93165963
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| ChEBI ID |
ChEBI:27584
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Aldosterone was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | MDR1 genotype-dependent regulation of the aldosterone system in humans. Pharmacogenet Genomics. 2007 Feb;17(2):137-44. | |||||
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