Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00590
|
|||||
| Drug Name |
Trimethoprim
|
|||||
| Synonyms |
AZT + TMP/SMX (mixture) combination; Abaprim; Alcorim-F; Alprim; Anitrim; Antrima; Antrimox; Apo-Sulfatrim; BW 56-72; BW 5672; BW-56-72; Bacdan; Bacidal; Bacide; Bacin; Bacta; Bacterial; Bacterial [Antibiotic]; Bacticel; Bactin; Bactoprim; Bactramin; Bencole; Bethaprim; Biosulten; Briscotrim; Chemotrin; Cidal; Co-Trimoxizole; Colizole; Colizole DS; Component of Bactrim; Component of Septra; Conprim; Cotrimel; Deprim; Duocide; Esbesul; Espectrin; Euctrim; Exbesul; Fermagex; Fortrim; Futin; Idotrim; Ikaprim; Instalac; KSC-4-158; KUC103659N; Kombinax; Lagatrim; Lagatrim Forte; Lastrim; Methoprim; Metoprim; Monoprim; Monotrim; Monotrim (TN); Monotrimin; NIH 204; NIH 204 (VAN); Novotrimel; Omstat; Oraprim; Pancidim; Polytrim; Priloprim; Primosept; Primsol; Proloprim; Proloprim (TN); Protrin; Purbal; Resprim; ResprimForte; Roubac; Roubal; Salvatrim; Septrin DS; Septrin Forte; Septrin S; Setprin; Sinotrim; Smz-Tmp; Stopan; Streptoplus; Sugaprim; Sulfamar; Sulfamethoprim; Sulfamethoxazole & Trimethoprim; Sulfoxaprim; Sulmeprim; Sulthrim; Sultrex; Syraprim; T 7883; TCMDC-125538; TMP; TMP/SMX (MIXTURE)); Tiempe; Tmp-Ratiopharm; Toprim; Trimanyl; Trimeth/Sulfa; Trimethioprim; Trimethopim(TMP); Trimethoprim & VRC3375; Trimethoprim (JAN/USP/INN); Trimethoprim [USAN:BAN:INN:JAN]; Trimethoprime; Trimethoprime [INN-French]; Trimethoprimum; Trimethoprimum [INN-Latin]; Trimethopriom; Trimetoprim; Trimetoprim [DCIT]; Trimetoprim [Polish]; Trimetoprima; Trimetoprima [INN-Spanish]; Trimexazole; Trimexol; Trimez-IFSA; Trimezol; Trimogal; Trimono; Trimopan; Trimpex; Trimpex (TN); Trimpex 200; Triprim; Triprim (TN); Trisul; Trisulcom; Trisulfam; Trisural; U-Prin; Uretrim; Uro-D S; Urobactrim; Utetrin; Velaten; WR 5949; Wellcoprim; Wellcoprin; Xeroprim; Zamboprim
|
|||||
| Drug Type |
Small molecular drug
|
|||||
| Indication | Urinary tract infections [ICD11:GC08] | Approved | [1] | |||
| Therapeutic Class |
Antiinfective Agents
|
|||||
| Structure |
|
 |
||||
| 3D MOL | 2D MOL | |||||
| Formula |
C14H18N4O3
|
|||||
| Canonical SMILES |
COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N
|
|||||
| InChI |
InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
|
|||||
| InChIKey |
IEDVJHCEMCRBQM-UHFFFAOYSA-N
|
|||||
| CAS Number |
CAS 738-70-5
|
|||||
| Pharmaceutical Properties | Molecular Weight | 290.32 | Topological Polar Surface Area | 106 | ||
| Heavy Atom Count | 21 | Rotatable Bond Count | 5 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 7 | |||
| XLogP |
0.9
|
|||||
| PubChem CID | ||||||
| PubChem SID |
10321479
,10534335
,11111923
,11111924
,11113621
,11335764
,11361003
,11363061
,11365623
,11368185
,11371565
,11374002
,11376347
,11461975
,11466236
,11467356
,11484610
,11485852
,11488753
,11490459
,11492187
,11493981
,14824824
,17389524
,17405825
,22391545
,24278201
,24870616
,24889615
,25623645
,26611964
,26680042
,26697109
,26704777
,26747124
,26747125
,26751820
,3146445
,406777
,4752045
,5066
,604810
,7847213
,7890832
,7980835
,8027414
,8149571
,8153433
,837167
,857743
|
|||||
| ChEBI ID |
ChEBI:45924
|
|||||
| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | 1-Oct | Transporter Info | Organic cation transporter 1 | Substrate | [2] | |
| P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [3] | ||
| References | ||||||
| 1 | Trimethoprim was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. | |||||
| 3 | Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. | |||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.