Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00586
|
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| Drug Name |
Nitrendipine
|
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| Synonyms |
1A Pharma, Nitren; AL, Nitrendipin; AbZ, Nitre; Acis, Nitren; Atid, Nitrendipin; Basics, Nitrendipin; Bay-e-5009; Baylotensin; Bayotensin; Baypress; Baypress (TN); Bayvit, Nitrendipino; Beta, Nitrendipin; Biochemie, Nitrendi; Bylotensin; Ct, nitrendipin von; Deiten; Gericin; Heumann, Nitrendipin; Jutapress; KSK, Nitrend; Lich, Nitren; Lindo, Nitrendipin; N-144; Nidrel; Niprina; Nitre AbZ; Nitre Puren; Nitre-Puren; NitrePuren; Nitregamma; Nitren 1A Pharma; Nitren Lich;Nitren acis; Nitrend KSK; Nitrendepat; Nitrendi Biochemie; Nitrendidoc; Nitrendimerck; Nitrendipin; Nitrendipin AL; Nitrendipin Apogepha; Nitrendipin Atid; Nitrendipin Basics; Nitrendipin Heumann; Nitrendipin Lindo; Nitrendipin Stada; Nitrendipin beta; Nitrendipin corax; Nitrendipin von ct; Nitrendipin-corax; Nitrendipincorax; Nitrendipino; Nitrendipino Bayvit; Nitrendipinum; Nitrensal; Nitrepin; Nitrepress; Pharma, Nitren 1A; Stada, Nitrendipin; Tensogradal; Trendinol; Vastensium; Von ct, nitrendipin
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| Drug Type |
Small molecular drug
|
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| Indication | High blood pressure [ICD11:BA00] | Approved | [1] | |||
| Therapeutic Class |
Antihypertensive Agents
|
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C18H20N2O6
|
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| Canonical SMILES |
CCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC)C)C
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| InChI |
InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3
|
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| InChIKey |
PVHUJELLJLJGLN-UHFFFAOYSA-N
|
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| CAS Number |
CAS 39562-70-4
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| Pharmaceutical Properties | Molecular Weight | 360.4 | Topological Polar Surface Area | 110 | ||
| Heavy Atom Count | 26 | Rotatable Bond Count | 6 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 7 | |||
| XLogP |
2.9
|
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| PubChem CID | ||||||
| PubChem SID |
10588972
,11120001
,11120489
,11120977
,11121464
,11121944
,11147084
,11342013
,11362196
,11362533
,11364838
,11365095
,11367400
,11367657
,11369962
,11370337
,11370338
,11371895
,11373258
,11374614
,11375819
,11378130
,11466944
,11468064
,11485206
,11486717
,11487598
,11489381
,11490783
,11492902
,11495715
,12013715
,14925926
,17405440
,24277857
,26612495
,26680401
,26719687
,26747121
,26751794
,26751795
,29223601
,46386549
,46508817
,5055566
,6014122
,7847695
,8152776
,855994
,9915
|
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| ChEBI ID |
CHEBI:7582
|
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Analogue-based Drug Discovery | |||||
| 2 | Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. | |||||
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