Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00572
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| Drug Name |
Chloroquine
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| Synonyms |
(+)-Chloroquine; (-)-Chloroquine; (R)-(-)-Chloroquine; 3377 RP opalate; 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline; 7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline; Amokin; Aralen; Aralen HCl; Arechin; Arechine; Arequin; Arolen; Arthrochin; Artrichin; Avlochlor; Avloclor; Bemaco; Bemaphate; Bemasulph; Benaquin; Bipiquin; CU-01000012392-2; Capquin; Chemochin; Chingamin; Chloraquine; Chlorochin; Chlorochine; Chlorochinum; Chloroin; Chloroquin; Chloroquina; Chloroquine (USP/INN); Chloroquine (VAN); Chloroquine Bis-Phosphoric Acid; Chloroquine FNA (TN); Chloroquine [USAN:INN:BAN]; Chloroquine phosphate; Chloroquinium; Chloroquinum; Chloroquinum [INN-Latin]; Chlorquin; Cidanchin; Clorochina; Clorochina [DCIT]; Cloroquina; Cloroquina [INN-Spanish]; Cocartrit; Dawaquin (TN); Delagil; Dichinalex; Elestol; Gontochin; Gontochin phosphate; Heliopar; Imagon; Ipsen 225; Iroquine; Khingamin; Klorokin; Lapaquin; Malaquin; Malaquin (*Diphosphate*); Malaren; Malarex; Mesylith; Miniquine; N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine; N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine; Neochin; Nivachine; Nivaquine B; Pfizerquine; Quinachlor; Quinagamin; Quinagamine; Quinercyl; Quingamine; Quinilon; Quinoscan; RP 3377; RP-3377; Resochen; Resochin; Resochin (TN); Resoquina; Resoquine; Reumachlor; Reumaquin; Rivoquine; Ro 01-6014/N2; Ronaquine; Roquine; SN 6718; SN-7618; ST 21; ST 21 (pharmaceutical); Sanoquin; Silbesan;Siragan; Solprina; Sopaquin; Tanakan; Tanakene; Tresochin; Trochin; W 7618;WIN 244; {4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine
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| Drug Type |
Small molecular drug
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| Indication | Malaria [ICD11:1F40] | Approved | [1] | |||
| Therapeutic Class |
Antimalarials
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C18H26ClN3
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| Canonical SMILES |
CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl
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| InChI |
InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)
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| InChIKey |
WHTVZRBIWZFKQO-UHFFFAOYSA-N
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| CAS Number |
CAS 54-05-7
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| Pharmaceutical Properties | Molecular Weight | 319.9 | Topological Polar Surface Area | 28.2 | ||
| Heavy Atom Count | 22 | Rotatable Bond Count | 8 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 3 | |||
| XLogP |
4.6
|
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| PubChem CID | ||||||
| PubChem SID |
10526125
,11335579
,11360818
,11363006
,11365568
,11368130
,11371321
,11373917
,11376292
,11404351
,11405289
,11461790
,11466576
,11467696
,11483910
,11486252
,11487943
,11490157
,11492094
,11493946
,11528736
,14776983
,26675665
,29221876
,447935
,46506925
,47217037
,47291356
,47440521
,47440522
,47885638
,48035387
,48110720
,48185227
,48259487
,49635547
,49681217
,49698849
,49846799
,50111008
,5050990
,53787949
,53788124
,56310729
,57321414
,596572
,7849425
,7978921
,8151759
,9827
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| ChEBI ID |
ChEBI:3638
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | MATE1 | Transporter Info | Multidrug and toxin extrusion protein 1 | Substrate | [2] | |
| P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [3] | ||
| References | ||||||
| 1 | Chloroquine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine. Antimicrob Agents Chemother. 2011 Jul;55(7):3091-8. | |||||
| 3 | Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. | |||||
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