Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00561
|
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| Drug Name |
Phenformin
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| Synonyms |
1-(diaminomethylidene)-2-phenethylguanidine; 1-Phenethylbiguanide; Azucaps; Beta-PEBG; Beta-Phenethybiguanide; Beta-Phenethylbiguanide; Cronoformin; D Bretard; DB Comb; DBI; DBI monohydrochloride; Db-retard; Debeone; Debeone (TN); Debinyl; Diabis; Dibein; Dibiraf; Dibotin; Dipar; Feguanide; Fenfoduron; Fenformin; Fenformina; Fenformina [INN-Spanish]; Fenormin; Glukopostin; Glyphen; Insoral; Lentobetic; Meltrol; Meltrol-50; N'-beta-Fenetilformamidiniliminourea; N'-beta-Fenetilformamidiniliminourea [Italian]; N'-beta-Phenethylformamidinylliminourea; N-(2-Phenylethyl)imidodicarbonimidic diamide; N-Phenethylbiguanide hydrochloride; Normoglucina; PHENFORMIN (SEE ALSO PHENFORMIN HYDROCHLORIDE 834-28-6); Pedg; Phenethyldiguanide; Phenformin (BAN); Phenformin [INN:BAN]; Phenformine; Phenformine HCl; Phenformine [INN-French]; Phenforminum; Phenforminum [INN-Latin]; Phenformix; Phenoformine hydrochloride; Phenylethylbiguanide; Retardo; W 32
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| Drug Type |
Small molecular drug
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| Indication | Diabetes [ICD11:5A10-5A14] | Withdrawn | [1] | |||
| Therapeutic Class |
Hypoglycemic Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C10H15N5
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| Canonical SMILES |
C1=CC=C(C=C1)CCN=C(N)N=C(N)N
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| InChI |
InChI=1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)
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| InChIKey |
ICFJFFQQTFMIBG-UHFFFAOYSA-N
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| CAS Number |
CAS 114-86-3
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| Pharmaceutical Properties | Molecular Weight | 205.26 | Topological Polar Surface Area | 103 | ||
| Heavy Atom Count | 15 | Rotatable Bond Count | 4 | |||
| Hydrogen Bond Donor Count | 3 | Hydrogen Bond Acceptor Count | 1 | |||
| XLogP |
-0.8
|
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| PubChem CID | ||||||
| PubChem SID |
103426218
,104098499
,104317320
,10504499
,11112448
,11364804
,11367366
,11369928
,11372968
,11375528
,11378095
,11466207
,11467327
,11485734
,117524452
,117879477
,124882390
,124882391
,124882392
,125325517
,125823034
,126687817
,128146967
,131850042
,134223094
,134337521
,134974542
,14773187
,29226965
,4583360
,46505230
,47217161
,47736859
,47811132
,47960115
,47960116
,48416408
,49698378
,49854764
,50100445
,57288470
,57324876
,615911
,78063341
,85787916
,88835501
,94569120
,96025038
,9875
,99452969
|
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| ChEBI ID |
CHEBI:8064
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | 1-Oct | Transporter Info | Organic cation transporter 1 | Substrate | [2] | |
| References | ||||||
| 1 | Drug information of Phenformin, 2008. eduDrugs. | |||||
| 2 | Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. | |||||
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