Drug Information

General Information
Drug ID
DR00541
Drug Name
Loratadine
Synonyms
1-Piperidenecarboxylic acid, 4-(8-chloro-5,6-duhydro-11H-benzo [5,6]cyclohepta[1,2-b]-pyridin-11-ylidene)-, ethyl ester; 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester; 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester; 1-piperidinecarboxylic acid,4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-,ethyl ester; 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester; 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acidethyl ester; 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cycloheptal[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester; Aerotina; Alarin; Alavert; Alavert (TN); Alavert, Claritin, Loratadine; Alerpriv; AllergyX (TN); Allertidin; Anhissen; Bedix Loratadina; Biloina; Bonalerg; Children's Claritin; Civeran; Claratyne; Claratyne Cold; Claratyne Decongestant; Clarinase; Clarinase Reperabs; Claritin; Claritin (TN); Claritin D; Claritin Hives Relief; Claritin Hives Relief Reditab; Claritin Reditabs; Claritin reditab; Claritin-D (TN); Claritine (TN); Claritine;Clarityn; Clarityn (TN); Clarityne; Clarityne (TN); Clarityne Dy Repetabs; Clarityne-D; Clarium; Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate;Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate; Flonidan (TN); Fristamin; Fristamin (TN); Histaloran; L 9664; Lergy; Lertamine; Lesidas; Lisino; Lomilan (TN); Loracert; Loradex; Loradif; Loranox; Lorantis; Lorastine; Loratadina; Loratadina [Spanish]; Loratadine (JAN/USAN/INN); Loratadine Redidose; Loratadine Wyeth Brand; Loratadine [USAN:BAN:INN]; Loratadinum; Loratadinum [Latin]; Loratidine; Loratyne; Loraver; Lorfast; Lorfast (TN); Loritine; Lowadina; Nularef; Optimin; Polaratyne; Pylor; Restamine; Rhinase; Rinolan (TN); Rinomex; Roletra; Roletra (TN); Sanelor; Sch 29851; Sch-29851; Sch29851; Sensibit; Sinhistan Dy; Sohotin; Symphoral (TN); Tadine; Talorat Dy; Tidilor (TN); Velodan; Versal; Wyeth Brand of Loratadine; Zeos
Drug Type
Small molecular drug
Indication Allergy [ICD11:4A8Z] Approved [1]
Therapeutic Class
Antihistamines
Structure
3D MOL 2D MOL
Formula
C22H23ClN2O2
Canonical SMILES
CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
InChI
InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChIKey
JCCNYMKQOSZNPW-UHFFFAOYSA-N
CAS Number
CAS 79794-75-5
Pharmaceutical Properties Molecular Weight 382.9 Topological Polar Surface Area 42.4
Heavy Atom Count 27 Rotatable Bond Count 2
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 3
XLogP
5.2
PubChem CID
3957
PubChem SID
11111394 ,11113345 ,11335967 ,11361206 ,11364390 ,11366952 ,11369514 ,11371620 ,11373832 ,11377676 ,11445825 ,11462178 ,11485284 ,11489400 ,11490556 ,11491992 ,11495310 ,11528699 ,1197563 ,12013131 ,14804759 ,17405241 ,24278525 ,25623638 ,26612522 ,26680506 ,26719690 ,26747010 ,26751528 ,29223071 ,46386837 ,46507853 ,47365230 ,48035159 ,48110481 ,48110482 ,48259268 ,48416183 ,4964188 ,49835216 ,49846690 ,50100268 ,50104102 ,50104103 ,535878 ,7847430 ,7979793 ,8150042 ,8152484 ,855843
ChEBI ID
CHEBI:6538
TTD Drug ID
D06ABF
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
References
1 Loratadine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab Dispos. 2003 Mar;31(3):312-8.

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